What's Your Sunscreen IQ? Know These Facts.

Here are some quick facts about sunscreen from the American Society of Aesthetic Plastic Surgery . To protect your skin from the sun's damaging rays, apply sunscreen at least 20 minutes before sun exposure and reapply every few hours. Here are the important facts. What does UV mean? Before you select an effective sunscreen, you should know Ultraviolet (UV) radiation that affects the skin are classified as UVA and UVB. What is UVA? UVA is the longest of the UV.   It can penetrate into the deeper layers of the skin and plays a major role in skin aging and wrinkling.   Recent studies show it causes the development of skin cancer.   UVA penetrates glass and clouds. What is UVB? UVB is responsible for burning, tanning, accelerating the skin aging and also plays a key role in the development of skin cancer.   UVB varies by season, location and time of day.   The most intense amount of UVB hits the U.S. between 10:00am and 4:00PM. What is SPF? Sun Protection factor (SPF) measures the protection provided by a sunscreen against UVB.   It is defined as the ratio of how long it takes for skin to redden with sunscreen compared to without sunscreen. Although the SPF ratings found on sunscreen packages apply mainly to UVB rays, many sunscreen manufacturers include ingredients that protect the skin from some UVA rays as well.   Higher SPF numbers are preferable, but don ’t let an inflated number lull you into a false sense of security, espec...
Source: What's New In Plastic Surgery? - Category: Cosmetic Surgery Tags: sunscreen Source Type: blogs

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Publication date: March 2020Source: Materials Science and Engineering: C, Volume 108Author(s): Sudip Mukherjee, Rajesh Kotcherlakota, Shagufta Haque, Dwaipayan Bhattacharya, Jerald Mahesh Kumar, Sumana Chakravarty, Chitta Ranjan PatraAbstractEfficient delivery of chemotherapeutic drugs to tumor cells is one of the crucial issues for modern day cancer therapy. In this article, we report the synthesis of poly ethylene glycol (PEG) assisted colloidal platinum nanoparticles (PtNPs) by borohydride reduction method at room temperature. PtNPs are stable at room temperature for more than 2 years and are stable in serum and phospha...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 20 November 2019Source: Journal of Advanced ResearchAuthor(s): Sohail Mumtaz, Pradeep Bhartiya, Neha Kaushik, Manish Adhikari, Pradeep Lamichhane, Su-Jae Lee, Nagendra Kumar Kaushik, Eun Ha ChoiAbstractOver the past few decades, microwave (MW) radiation has been widely used, and its biological effects have been extensively investigated. However, the effect of MW radiation on human skin biology is not well understood. We study the effects of pulsed high-power microwaves (HPMs) on melanoma (G361 and SK-Mel-31) and normal human dermal fibroblast (NHDF) cells. A pulsed power generator (Chundo...
Source: Journal of Advanced Research - Category: Research Source Type: research
CONCLUSIONS Our data demonstrate an oncogenic role of miR-652 in uveal melanoma, showing that miR-652 may be a useful biomarker for prediction of prognosis for patients with uveal melanoma. PMID: 31740654 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
ConclusionsMG is a life-threatening adverse event of acute onset and rapid progression after ICI initiation. Early use of IVIG or PLEX, regardless of initial symptoms severity, may lead to better outcomes than steroids alone. Our data suggest the need to reassess the current recommendations for management of ICI-related MG until prospective longitudinal studies are conducted to establish the ideal management approach for these patients.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
AbstractPurposeThe linkage between the genetic and phenotypic heterogeneity of the tumor has not been thoroughly evaluated. Herein, we investigated how the genetic and metabolic heterogeneity features of the tumor are associated with each other in head and neck squamous cell carcinoma (HNSC). We further assessed the prognostic significance of those features.MethodsThe mutant-allele tumor heterogeneity (MATH) score (n = 508), a genetic heterogeneity feature, and tumor glycolysis feature (GlycoS) (n = 503) were obtained from the HNSC dataset in the cancer genome atlas (TCGA). We identified matchin...
Source: EJNMMI Research - Category: Radiology Source Type: research
n-Anezin Oncogene-induced STAT3-activation is central to tumor progression by promoting cancer cell expression of pro-angiogenic and immunosuppressive factors. STAT3 is also activated in infiltrating immune cells including tumor-associated macrophages (TAM) amplifying immune suppression. Consequently, STAT3 is considered as a target for cancer therapy. However, its interplay with other STAT-family members or transcription factors such as NF-κB has to be considered in light of their concerted regulation of immune-related genes. Here, we discuss new attempts at re-educating immune suppressive tumor-associated m...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Conclusions: Our findings suggest that some subsets of XPD patients may be at risk of radiosensitivity reactions and treatment with statins and bisphosphonates may be an interesting approach of radioprotection countermeasure. Different mechanistic models were discussed to better understand the potential specificity of the p.[Arg683Trp];[Arg616Pro] XPD mutations . PMID: 31738647 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Conclusions: Buparlisib was well tolerated, however efficacy was limited despite selection of PI3K pathway aberrations. Future studies may provide insight into buparlisib efficacy by refining the molecular selection of different tumor types. PMID: 31741715 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
In conclusion, our findings clarified the biologic significance of LINC00460/miR-612/AKT2 axis in HNSCC progression and provided novel evidence that LINC00460 may be a new potential therapeutic target for HNSCC. PMID: 31737186 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Publication date: 19 November 2019Source: Cell Reports, Volume 29, Issue 8Author(s): Anchal Sharma, Elise Merritt, Xiaoju Hu, Angelique Cruz, Chuan Jiang, Halle Sarkodie, Zhan Zhou, Jyoti Malhotra, Gregory M. Riedlinger, Subhajyoti DeSummaryImpacts of genetic and non-genetic intra-tumor heterogeneity (ITH) on tumor phenotypes and evolvability remain debated. We analyze ITH in lung squamous cell carcinoma at the levels of genome, transcriptome, and tumor-immune interactions and histopathological characteristics by multi-region bulk and single-cell sequencing. Genomic heterogeneity alone is a weak indicator of intra-tumor no...
Source: Cell Reports - Category: Cytology Source Type: research
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