High HIF-1 & #945; expression genotypes increase odds ratio of oral cancer.

Conclusions: In conclusion, ou r study demonstrated that the T and A alleles of C1772T and G1790A polymorphisms of the HIF-1 & alpha; gene increased the risk of ED and OSCC. C1772T and G1790A polymorphisms of the HIF-1 & alpha; gene had differing patterns of allelic imbalance in the precancerous lesions and subsequent carcinoma, suggesting a complex genetic pattern of progression from dysplasia to carcinoma. These findings suggest an additional role for HIF-1 & alpha; in OSCC development. Further studies are necessary to elucidate the HIF-1 & alpha; pathway in carcinogenesis, which would facilitate the development of novel therapeutic strategies for the prevention and treatment of OSCC and other solid tumors
Source: Head and Neck Oncology - Category: Cancer & Oncology Source Type: research