High hypoxia-inducible factor-1 & #945; expression genotype associated with Eastern Cooperative Oncology Group performance in head and neck squamous cell carcinoma.

Conclusions: In conclusion, our study demonstrated that the C1772T and polymorphism of the HIF-1 & alpha; gene are associated with poor ECOG-PS. Our data suggests that the presence of the TT genotype in HNSCC individuals might contribute to the higher clinical aggressiveness of malignant disease. Such findings may have implications for interruptions in the disease process and modifications in treatment regiments.
Source: Head and Neck Oncology - Category: Cancer & Oncology Source Type: research