Abstract < /h3 > < p class= " a-plus-plus " > More than 40  years ago Lynch et al. described several multigenerational breast cancer family pedigrees which demonstrated autosomal dominant inheritance of a trait(s) that increased risks for both breast and ovarian cancers. Mutation carriers in at least 90 % of these hereditary breast ovarian cancer (HBOC) s yndrome fa..."> Abstract < /h3 > < p class= " a-plus-plus " > More than 40  years ago Lynch et al. described several multigenerational breast cancer family pedigrees which demonstrated autosomal dominant inheritance of a trait(s) that increased risks for both breast and ovarian cancers. Mutation carriers in at least 90 % of these hereditary breast ovarian cancer (HBOC) s yndrome fa..." /> Abstract < /h3 > < p class= " a-plus-plus " > More than 40  years ago Lynch et al. described several multigenerational breast cancer family pedigrees which demonstrated autosomal dominant inheritance of a trait(s) that increased risks for both breast and ovarian cancers. Mutation carriers in at least 90 % of these hereditary breast ovarian cancer (HBOC) s yndrome fa..." />

M üllerian intra-abdominal carcinomatosis in hereditary breast ovarian cancer syndrome: implications for risk-reducing surgery

< h3 class= " a-plus-plus " > Abstract < /h3 > < p class= " a-plus-plus " > More than 40  years ago Lynch et al. described several multigenerational breast cancer family pedigrees which demonstrated autosomal dominant inheritance of a trait(s) that increased risks for both breast and ovarian cancers. Mutation carriers in at least 90 % of these hereditary breast ovarian cancer (HBOC) s yndrome families have been linked to cancer-associated mutations in the genes < em class= " a-plus-plus " > BRCA1 < /em > and < em class= " a-plus-plus " > BRCA2 < /em > . This review focuses on the contributions of Lynch, colleagues and collaborators and pertinent literature, toward defining the HBOC syndrome, the cancer risks that the inherited adverse mutations convey, the gynecologic tissues and organs from which the malignancy may arise to disseminate throughout the pelvic and abdominal organs and peritoneum and how this information can be used to reduce the risk and morbidities of intra-abdominal carcinomatosis in effected individuals. < /p >
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research