What ’s the best way to quit smoking?

Smoking cigarettes contributes to almost 1 in 5 deaths. The top three smoking-related causes of death are cardiovascular disease, lung cancer, and chronic obstructive pulmonary disease (COPD). In addition to these “top three,” smoking is also linked to a number of other cancers, an increased likelihood of getting more colds and infections, diabetes, osteoporosis and hip fractures, problems in pregnancy, difficulty with erections, stomach ulcers, gum disease, and the list goes on. Quitting smoking can add years to your life. Though the earlier the better, it’s never too late to quit. The benefits of quitting are real, even at the age of 80! So what’s the best way to quit? Set a quit date Pick a date in the next few weeks, share it with your friends and your family, and mark it on your calendar. Plan to completely stop smoking on that quit date. Think about what might make it challenging to stop. Be prepared for how you will handle any withdrawal symptoms. Identify what triggers your craving for a cigarette, and have a strategy to avoid or deal with these triggers. Start exercising before your quit date to minimize weight gain when you stop smoking. Find healthy distractions to keep your mind and hands busy. Have nicotine replacement products like nicotine gum and patches ready on hand if you plan to use them. Going “cold turkey” might be better You can choose to cut down on your cigarettes gradually before your quit date, or smoke as you nor...
Source: New Harvard Health Information - Category: Consumer Health News Authors: Tags: Addiction Behavioral Health Lung disease Prevention Smoking cessation Source Type: news

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Yoshio Yamauchi, Maximillian A. Rogers
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Research, published inMenopause, suggests that women who are not deficient in Vitamin D have a lower risk of developing breast cancer.MedicalXpress
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Mechanisms which link type-2 diabetes and decreasing brain function, may be small vessel disease in the brain, increased blood pressure and poor kidney function, according to research published inDiabetic Medicine. MedicalXpress
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Publication date: December 2018Source: Biomedicine &Pharmacotherapy, Volume 108Author(s): Wei Ren, Dong Wang, Chan Li, Tao Shu, Wei Zhang, Xiaoliang FuAbstractAccumulating evidence reports that Capn4 plays an important role in the development and progression of various malignant cancers. However, whether Capn4 is involved in prostate cancer remains unclear. Therefore, the aim of this study was to investigate the expression, biological function and regulatory mechanism of Capn4 in prostate cancer. Herein, we found that Capn4 was highly expressed in prostate cancer cell lines compared with normal prostate cells. Capn4 ge...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: December 2018Source: Biomedicine &Pharmacotherapy, Volume 108Author(s): Chien-Ying Lee, Chun-Hung Su, Ping-Kun Tsai, Ming-Ling Yang, Yung-Chyuan Ho, Shiuan-Shinn Lee, Chia-Hui Chen, Wen-Ying Chen, Meng-Liang Lin, Chun-Jung Chen, Chen-Yu Chian, Rosa Huang-Liu, Ya-Lan Chang, Yu-Hsiang KuanAbstractCigarette smoking is a well-established risk factor for various diseases, such as cardiovascular diseases, neurodegeneration, and cancer. Cadmium nitrate (Cd(NO3)2) is one of the major products from the cigarette smoke. Up to now, no supporting evidence on Cd(NO3)2-induced apoptosis and its related working mech...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: December 2018Source: Biomedicine &Pharmacotherapy, Volume 108Author(s): Charlette Tiloke, Krishnan Anand, Robert M. Gengan, Anil A. ChuturgoonAbstractCancer is classified as one of the leading causes of global mortality. It has affected millions of people, often with poor prognosis. Having severe side-effects with conventional chemotherapy, alternate drugs and therapies are actively being investigated. There is a need for innovative drug discovery and design as existing cancer therapies are costly and not readily available. Ayurveda and traditional medicine have utilised natural resources such as plan...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: November 2018Source: Biomedicine &Pharmacotherapy, Volume 107Author(s): Richarlisson Borges de Morais, Victor Pereira do Couto Muniz, Emerson Nunes Costa, Sebastião Rodrigues Ferreira Filho, Karen Renata Nakamura Hiraki, Luiz Borges Bispo-da-Silva, Ana Paula Coelho BalbiAbstractConsidering the importance of the renin-angiotensin system (RAS) in diabetic nephropathy (DN) and the link between mast cells (MC) and the RAS, this study evaluated the effects of RAS blockade on the MC cell population in the kidneys from rats with experimental diabetes. Wistar rats were divided into six groups: control ...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
In this study, we show that miR-590-3p was significantly decreased both in osteosarcoma tissues and cell lines, suggesting a potential role of miR-590-3p in osteosarcoma. Over-expression of miR-590-3p inhibited U2OS cell viability as shown by the CCK-8 assay and clonogenic assay. Ki-67 immunofluorescence staining and cell cycle analysis revealed that up-regulation of miR-590-3p inhibited U2OS cell proliferation. Transfection with miR-590-3p mimics suppressed PCNA, Cyclin D1 and CDK4 expression and increased p53 and p21 expression. In addition, U2OS cells transfected with miR-590-3p mimics exhibited reduced cell invasion an...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
In conclusion, Se-NPs could be a potent maternal prophylactic agent against the reduced total serum testosterone level and oxidative damage of Leydig cells induced by DBP via reducing the lipid peroxidation (LPO) and enhancing the antioxidant state in pre-pubertal male rat offspring.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
In conclusion, this study demonstrated that FBXL5 functioned as an oncogene in the progression of colon cancer through regulating PTEN/PI3K/AKT signaling.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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