Prenylflavone derivatives from the seeds of Psoralea corylifolia exhibited PPAR- γ agonist activity

Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Shunan Ma, Youwu Huang, Yuanyuan Zhao, Guoxin Du, Li Feng, Cheng Huang, Yiming Li, Fujiang Guo Three new prenylflavones 2(R,S)-4′-hydroxy-6,7-[2-(1-methoxy-1-methylethyl)-furano]-flavanone (1), 4′,7-dihydroxy-3′,5′-diprenyl-isoflavone (2) and 3,4′,7-trihydroxy-2-methoxy-3′-geranyl-isoflavanone (3), as well as 19 known ones were isolated and identified from the seeds of Psoralea corylifolia. In total, 22 prenylated molecules, including flavanones, isoflavones and chalcones analogues, were screened on the PPAR-γ agonist activity and their structure-activity relationship was also discussed. Graphical abstract

Source: Phytochemistry Letters - June 17, 2016 Category: Chemistry Source Type: research