Judge Rules Against AstraZeneca's Plea to Ban Crestor Generics

Generic manufacturers can now enter the $5 billion cholesterol drug market
Source: PharmaManufacturing.com - Category: Pharmaceuticals Source Type: news

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Conclusion The index might be a useful tool for assessing the nutritional quality of meals and for monitoring and comparing groups.RESUMO Objetivo Avaliar a validade interna e a confiabilidade do índice de qualidade das principais refeições. Métodos O indicador, Índice de Qualidade de Refeição, inclui dez componentes, com pontuação final que varia de 0 a 100 pontos. Estratégias de avaliação do desempenho do indicador incluíram: avaliação da validade de conteúdo, validade de construto, validade discriminante e con...
Source: Revista de Nutricao - Category: Nutrition Source Type: research
Abstract Background: Assessing the monocyte to high-density lipoprotein ratio (MHR) is a new tool for predicting inflamation, which plays a major role in atherosclerosis. Myocardial bridge (MB) is thought to be a benign condition with development of atherosclerosis, particularly at the proximal segment of the brigde. Objective: To evaluate the relationhip between MHR and the presence of MB. Methods: We consecutively scanned patients referred for coronary angiography between January 2013- December 2016, and a total of 160 patients who had a MB and normal coronary artery were enrolled in the study. The patients ’ angio...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Abstract Background: Assessing the monocyte to high-density lipoprotein ratio (MHR) is a new tool for predicting inflamation, which plays a major role in atherosclerosis. Myocardial bridge (MB) is thought to be a benign condition with development of atherosclerosis, particularly at the proximal segment of the brigde. Objective: To evaluate the relationhip between MHR and the presence of MB. Methods: We consecutively scanned patients referred for coronary angiography between January 2013- December 2016, and a total of 160 patients who had a MB and normal coronary artery were enrolled in the study. The patients ’ angio...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Adele Chimento, Ivan Casaburi, Paola Avena, Francesca Trotta, Arianna De Luca, Vittoria Rago, Vincenzo Pezzi, Rosa Sirianni
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
This study aims to assess changes in the hepa tic transcriptional profiles of mice that carry a whole-body phosphorylation deficient knock in mutant of LXRα (S196A) compared to wild-type (WT) upon being fed a HFHC diet.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
CONCLUSION: The study showed the potentials of VCO in the management of hyperlipidemia, renal and hepatic dysfunctions imposed by hyperglycemia and by oxidative stress in diabetic rats. PMID: 30659555 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
A portion of this article was previously published as part of an article titled “Human C-reactive protein and the metabolic syndrome” in the following journal: Curr Opin Lipidol. 2009 Jun;20(3):182-9.
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
Publication date: Available online 18 January 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Polly Zhang, Adam Schatz, Babatunde Adeyemi, David Kozminski, JoEllen Welsh, Martin Tenniswood, Wei-Lin Winnie WangAbstractVitamin D3 and its receptor are responsible for controlling energy expenditure in adipocytes and have direct roles in the transcriptional regulation of energy metabolic pathways. This phenomenon also has a significant impact on the etiology of prostate cancer (PCa). Using several in vitro models, the roles of vitamin D3 on energy metabolism and its implication in primary, early ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: Available online 18 January 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Liam Sharp, Reza Salari, Grace BranniganAbstractReconstituted nicotinic acetylcholine receptors (nAChRs) exhibit significant gain-of-function upon addition of cholesterol to reconstitution mixtures, and cholesterol affects organization of nAChRs within domain-forming membranes, but whether nAChR partitions to cholesterol-rich liquid-ordered (“raft” or lo) domains or cholesterol-poor liquid-disordered (ldo) domains is unknown. We use coarse-grained molecular dynamics simulations to observe spont...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Authors: Bian KY, Jin HF, Sun W, Sun YJ Abstract OBJECTIVE: To investigate the effect of tauroursodeoxycholic acid (TUDCA) on neurological impairment induced by acute cerebral infarction (ACI) and its relevant mechanism of action. PATIENTS AND METHODS: A total of 60 male Sprague-Dawley (SD) rats were randomly divided into Sham group (n = 20), ACI group (n = 20), and TUDCA group (n = 20). The rat model of ACI in middle cerebral artery was established. TUDCA was intravenously injected into rats in the TUDCA group, while an equal amount of sodium bicarbonate solution was intravenously injected into the other two g...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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