Minimal change disease: A case report of an unusual relationship.

We report a case of a 63-year-old male who presented with bilateral leg swelling due to nephrotic syndrome and acute kidney injury. A kidney biopsy showed minimal change disease with light chain deposition; however, no circulating light chains were present. This prompted a bone marrow biopsy, which showed chronic lymphocytic leukemia (CLL) with deposition of the same kappa monoclonal light chains. Three cycles of rituximab and methylprednisolone resulted in remission of both CLL and nephrotic syndrome, without recurrence during a three-year follow-up. PMID: 27424706 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/27424706?dopt=Abstract

Source: Saudi Journal of Kidney Diseases and Transplantation - June 30, 2016 Category: Urology & Nephrology Authors: Edrees F, Black RM, Leb L, Rennke H Tags: Saudi J Kidney Dis Transpl Source Type: research