The role of laparoscopy in the identification and management of missing accessory spleens after primary splenectomy: A case report and literature review

We present a 7-year-old boy with recurrent thrombocytopenia after primary laparoscopic splenectomy for immune thrombocytopenia (ITP). Imaging modalities (ultrasound, computed tomography scan, and scintigraphy) revealed two accessory spleens while the subsequent second laparoscopy revealed 11, which were successfully removed. The relevant medical literature is reviewed, and the value of laparoscopy for chronic ITP is highlighted.
Source: Journal of Indian Association of Pediatric Surgeons - Category: Surgery Authors: Source Type: research

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CONCLUSION This precision medicine approach identifies PI3K/Akt/mTOR signaling as the first pharmacologically targetable pathogenic process in IL-6 blockade–refractory iMCD. Prospective evaluation of sirolimus in treatment-refractory iMCD is planned (NCT03933904).FUNDING This study was supported by the Castleman’s Awareness &Research Effort/Castleman Disease Collaborative Network, Penn Center for Precision Medicine, University Research Foundation, Intramural NIH funding, and the National Heart Lung and Blood Institute.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
AbstractLusutrombopag (Mulpleta®), an orally bioavailable, small molecule thrombopoietin receptor agonist, is approved for the treatment of thrombocytopenia in adult patients with chronic liver disease who are scheduled to undergo a procedure. In placebo-controlled phase  3 clinical trials, lusutrombopag significantly increased the proportion of patients who did not require a platelet transfusion prior to the procedure or rescue therapy for bleeding up to 7 days after the scheduled procedure. Lusutrombopag also significantly increased the proportion of patients wh o were responders (i.e. had a platelet count&...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
Authors: Fogagnolo A, Taccone FS, Campo G, Montanari G, Capatti B, Ferraro G, Erriquez A, Ragazzi R, Creteur J, Volta CA, Spadaro S Abstract Coagulation disorders and thrombocytopenia are common in patients with septic shock, but only few studies have focused on platelet variables beyond platelet count. The aim of this study was to evaluate whether platelets reactivity predicts sepsis-induced thrombocytopenia in patients with septic shock. We therefore enrolled consecutive patients with septic shock and platelets count>150*103/μL on the day of the diagnosis. Platelets reactivity tests were performed daily fro...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
Authors: Sousa SM, Sousa TM, Silva CF, Mendes CC Abstract Thrombocytopenia is a clinically important condition that can lead to several problems when not correctly diagnosed. A decrease of platelet counts due to an in vitro phenomenon, Pseudothrombocytopenia, can be misunderstood and unnecessarily treated. The present case study describes a 57-year-old male with a history of pancreas adenocarcinoma and a current Staphylococcus aureus infection without any signs or symptoms that could explain the low levels of platelets obtained after blood analysis. Blood smear evaluation detected both platelet satellitism and phag...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
Condition:   ITP Intervention:   Drug: TPO Sponsor:   Shenyang Sunshine Pharmaceutical Co., LTD. Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 12 September 2019Source: Genes &DiseasesAuthor(s): Kanika Arora, Sandesh Guleria, Ankur Kumar Jindal, Amit Rawat, Surjit SinghAbstractKawasaki disease (KD) is a medium vessel vasculitis with predilection to cause coronary artery abnormalities. KD is now the most common cause of acquired heart disease in developed countries. Thrombocytosis is consistently found in patients with KD, usually in 2nd to 3rd week of illness. Thrombocytopenia has occasionally been reported in the acute phase of KD. An increase or decrease in platelet number in patients with KD was initially considered to be ...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
This study demonstrates that using platelet count to predict the fatality of H7N9 is significant, and lower platelet counts of H7N9 patients were associated with higher risk of mortality of H7N9 patients, which may need to be taken into consideration when planning clinical treatment. PMID: 31509040 [PubMed - as supplied by publisher]
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
ConclusionsSarcopenia was predictive for neutropenia associated with GC or GCa in UC patients and OS in metastatic UC.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
Congenital Dyserythropoietic Anemia (CDA) is a heterogeneous group of hematological disorders characterized by chronic hyporegenerative anemia and distinct morphological abnormalities of erythroid precursors in the bone marrow. In many cases, a final diagnosis is not achieved due to different levels of awareness for the diagnosis of CDAs and lack of use of advanced diagnostic procedures. Researchers have identified five major types of CDA: types I, II, III, IV, and X-linked dyserythropoietic anemia and thrombocytopenia (XLDAT). Proper management in CDA is still unsatisfactory, as the different subtypes of CDA have differen...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
ConclusionsThe occurrence of thrombocytopenia was strongly determined by various aPL profiles in SLE patients. While the association between IgM antibodies and other APS manifestations including thrombosis is debated, IgM isotypes are helpful in the risk stratification of thrombocytopenia in SLE.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
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