Aggressive cervical neuroblastoma with a rare paraneoplastic syndrome: A therapeutic dilemma

We present an interesting case of an unrelenting cervical neuroblastoma associated with HD, which posed a therapeutic challenge.
Source: Journal of Indian Association of Pediatric Surgeons - Category: Surgery Authors: Source Type: research

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Conclusion: A high index of suspicion in appropriate clinical circumstances and early aggressive immunomodulation might lead to a better outcome.
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
Opsoclonus-myoclonus-ataxia syndrome (OMAS), or dancing eyes syndrome, is a rare neurological disorder characterized by irregular multidirectional eye movements, myoclonus, and, less frequently, cerebellar ataxia, sleep disturbances, and cognitive dysfunction (Gorman, 2010). OMAS, first described in 1962, has classically been related to neuroblastoma in children as a paraneoplastic syndrome. Post-infectious OMAS, with benign recovery, has occasionally been described, including virus-associated OMAS following infection caused by dengue virus (DENV) (Tan et al., 2014) and other viruses (Gorman, 2010).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case Report Source Type: research
AbstractObjectiveThe aim of this study was to describe specificities of patients with NMDA receptor antibody (NMDAR-Ab) encephalitis associated with a malignant tumor.MethodsRetrospective observational study of 252 patients with NMDAR-Ab encephalitis of the French Paraneoplastic Neurological Syndrome Reference Center. Patients were classified in three groups: (1) non-malignant ovarian teratomas, (2) malignant ovarian teratomas (immature), and (3) other malignant tumors.ResultsSixty patients (23.8%) had an associated tumor and 15 (6%) were malignant. No particular neurological symptom was observed in these patients. Ovarian...
Source: Journal of Neurology - Category: Neurology Source Type: research
No abstract available
Source: Medicine - Category: Internal Medicine Tags: Erratum Source Type: research
We reported a histologically unusual heterogeneous tumor that comprised ONB and craniopharyngioma. This is the first reported case of PLE with anti-Hu antibodies possibly associated with ONB admixed with craniopharyngioma.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Abstract Opso-myoclonus syndrome (OMS) is a very rare and severe condition. Ataxia, opsoclonus, myoclonus and/or behavioral and sleeping disturbances define that autoimmune disorder syndrome which is paraneoplastic or triggered by an infection. Here, we report a 3 year-old immunocompetent boy who developed an atypical OMS which was later complicated by an acute transverse myelitis. Screening for neuroblastoma was negative and extensive infectious screening revealed an active HHV-6 infection confirmed by blood and cerebrospinal fluid PCR. A parainfectious disease was suggested and immunosuppressive treatment was in...
Source: European Journal of Paediatric Neurology - Category: Neurology Authors: Tags: Eur J Paediatr Neurol Source Type: research
AbstractThe autonomic nervous system (ANS) is the main homeostatic regulatory system of the body. However, this widely distributed neural network can be easily affected by cancer and by the adverse events induced by cancer treatments. In this review, we have classified the ANS complications of cancer into two categories. The first includes direct cancer-related complications, such as primary ANS tumors (pheochromocytoma, paraganglioma or neuroblastoma), as well as autonomic manifestations induced by non-primary ANS tumors (primary brain tumors and metastases). The second comprises indirect ANS complications, which include ...
Source: Clinical Autonomic Research - Category: Research Source Type: research
In Reply We thank Drs Kim and Budhram for their valuable suggestion. Owing to the 600-word limit in the Observation section, much of the information associated with this patient had to be omitted in the article. Herein we fill in some of the gaps. We agree that magnetic resonance imaging is the first priority for excluding a paraneoplastic or parainfectious origin when treating a patient with opsoclonus. Small cell carcinoma of the lung, breast cancer, and ovarian cancer are most prevelent in adults with opsoclonus, whereas neuroblastoma accounts for more than 50% prevalence in children. Of course, such work-up had been do...
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
Paraneoplastic neurologic disorders have been at the frontier of neuroimmunology for decades and remain urgent. Newer tools for the diagnosis and treatment of neuroinflammation include autoantibody screening, lymphocyte subset analysis, oligoclonal bands, and profiling of chemokines/cytokines and brain-related proteins in CSF and blood/serum. Opsoclonus-myoclonus syndrome (OMS), a paraneoplastic disorder without a known diagnostic antibody marker, is associated with remote neuroblastoma and is often relapsing.1 Paraneoplastic encephalomyelitis with type 1 antineuronal nuclear antibodies (ANNA-1) (alias anti-Hu)2 also may o...
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Paraneoplastic syndrome Clinical/Scientific Notes Source Type: research
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Source: Scandinavian Journal of Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the Editor Source Type: research
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