ADGRL3 (LPHN3) variants are associated with a refined phenotype of ADHD in the MTA study

ConclusionThe detection of susceptibility conferred by ADGRL3 variants in the extreme phenotype of continued diagnosis of ADHD‐C from childhood to adolescence provides additional support that the association of ADGRL3 and ADHD is not spurious. Exploring genetic effects in longitudinal cohorts, in which refined, age‐dependent phenotypes are documented, is crucial to understand the natural history of ADHD. ADGRL3 (LPHN3) variants are associated with ADHD susceptibility in cross‐sectional studies and in longitudinal studies. Evidence from a large longitudinal study is present in this publication.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fmgg3.230

Source: Molecular Genetics & Genomic Medicine - June 30, 2016 Category: Genetics & Stem Cells Authors: Maria T. Acosta, James Swanson, Annamarie Stehli, Brooke S. G. Molina, , Ariel F. Martinez, Mauricio Arcos‐Burgos, Maximilian Muenke Tags: Original Article Source Type: research