DoD Epilepsy Idea Development Award

Funding Opportunity ID: 286247 Opportunity Number: W81XWH-16-ERP-IDA Opportunity Title: DoD Epilepsy Idea Development AwardOpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementGrantCategory of Funding Activity: Science and Technology and other Research and DevelopmentCategory Explanation: CFDA Number(s): 12.420Eligible Applicants: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"Additional Information on Eligibility: Agency Code: DOD-AMRAAAgency Name: Department of DefenseDept. of the Army -- USAMRAAPosted Date: Jul 18, 2016Close Date: Nov 09, 2016Last Updated Date: Jul 18, 2016Award Ceiling: $0Award Floor: $0Estimated Total Program Funding: $6,800,000Expected Number of Awards: 5Description: The ERP Idea Development Award (IDA) mechanism was first offered in FY15. Since then, 24 IDA applications have been received, and 5 have been recommended for funding. The intent of the ERP IDA is to solicit research to understand the magnitude and underlying mechanisms of PTE, especially in Service members and Veterans while also benefitting the civilian community. To this end, the ERP has identified FY16 Focus Areas by which the intent of the IDA mechanism can be facilitated (see Section I.B., FY16 ERP IDA Focus Areas). These should be carefully considered as part of the application proce...
Source: Grants.gov - Category: Research Tags: Science and Technology and other Research and Development Source Type: funding

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ConclusionsEpilepsy and seizure-related deaths are underreported in the Australian Coronial system. Enhanced documentation of the causal chain of events leading to deaths would increase recognition. Using the unified SUDEP definition would expand SUDEP identification.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
CONCLUSIONS: Epilepsy and seizure-related deaths are underreported in the Australian Coronial system. Enhanced documentation of the causal chain of events leading to deaths would increase recognition. Using the unified SUDEP definition would expand SUDEP identification. PMID: 31408827 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
CONCLUSIONS: Study design issues and limited information presented in the included studies mean that our results provide limited evidence to aid patient selection for surgery and prediction of likely surgical outcomes. Future research should be of high quality, follow a prospective design, be appropriately powered, and focus on specific issues related to diagnostic tools, the site-specific surgical approach, and other issues such as extent of resection. Researchers should investigate prognostic factors related to the outcome of surgery via multi-variable statistical regression modelling, where variables are selected for mo...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
INTRODUCTION: The causes of falls and resultant head injuries in people with epilepsy are complex and represent important clinical issues significantly impacting on safety, quality of life and long-term prognosis. A general solution for many years has been...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
ConclusionsSeizure-related head injury, although rare, may have serious consequences. High doses of antiepileptic/antiseizure drugs (AEDs/ASDs) and a prescription for three or more AEDs/ASDs are significant, modifiable, risk factors for head injury. Differentiating confusion due to post-ictal changes or concussion can be challenging. Seizure-related cardiac causes leading to injury due to ictal bradycardia or asystole is under investigated. More research is required to validate the protective benefit of various helmet designs in seizure-related head injury. It is striking that there are no International Standards for prote...
Source: Seizure - Category: Neurology Source Type: research
ConclusionPatients with PNES may frequently report auras including some auras which are often seen in patients with focal epilepsies; as a result, they are at great risk of receiving wrong diagnosis and unnecessary treatments. Health care professionals involved in the management of patients with seizures should be aware of this risk and prescribe an antiepileptic drug only after making a definite diagnosis of epilepsy in a patient with a paroxysmal event.
Source: Seizure - Category: Neurology Source Type: research
Conclusions: Prefrontal gyrification is reduced in children with ADHD who also carry the DRD4 7R allele, and it relates to critical functional skills in the executive domain in carriers of the risk allele. More broadly, these effects highlight the importance of considering precise neurodevelopmental mechanisms through which risk alleles influence cortical neurogenesis and migration.IntroductionAttention deficit/hyperactivity disorder (ADHD) is a heterogeneous neuropsychiatric disorder characterized by developmentally inappropriate symptoms of inattention, impulsivity, and hyperactivity. The disorder is thought to affect ar...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusion The willingness of young males to engage in dangerous situations might be adaptive in terms of fitness maximization. Nonetheless, for some individuals this intense sexual competition can be detrimental to health. The correspondence between the age distribution of the reproductively most active population and those suffering sTBI only partially supports the evolutionary hypothesis about risk-taking behavior. The prevalence of higher external mortality rates of young males, on the other hand, was not present in our data at all, nor did we find any support for the assumption that sTBI acquired from riskier behavio...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: Taiwanese patients with PTE had approximately 2 times the mortality risk and an increased medical burden compared to patients with TBI only. Our findings provide crucial information for clinicians and the government to improve TBI outcomes.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
​BY JORDAN DEMCHUKA 59-year-old Caucasian man with a past medical history of well-controlled hypertension, hyperlipidemia, and gout presented to the ED with altered mental status. His wife reported that he was found two hours earlier in his home office confused, unable to recall plans made that morning, the current time and date, and his brother's death a year and a half earlier. She stated that the patient was repeating, “I don't know what's happening,” while anxiously pacing around the room. She said he had a history of falls and head injury at age 7, which was accompanied by brief amnesia that had not recu...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
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