Log in to search using one of your social media accounts:

 

Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients.

This study shows that while any single specific bone marrow failure/myelodysplastic syndrome genetic disorder is rare, screening for these disorders in aggregate identifies a significant subset of patients with inherited bone marrow failure/myelodysplastic syndrome. PMID: 27418648 [PubMed - as supplied by publisher]
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research

Related Links:

Conclusion: Risk factors and a more advanced clinical stage of USCC have an impact on poor outcomes despite the use of standard treatment methods, adapted for cervical cancer. The outside-pelvic failures tend to seek effective systemic treatment.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - Category: OBGYN Source Type: research
BOSTON (CBS) – It’s a parent’s worst nightmare, hearing not only that your child has cancer but that she might also lose her eye. That’s exactly what happened to an Andover family and their 3-year-old daughter. But as Dr. Mallika Marshall reports, doctors at Boston Children’s Hospital are using a revolutionary technique to try to save her vision and her life. A little over a year ago Dania Snyder was a typical toddler until her parents noticed something unusual about her right eye. “You could see a little flash of a fleshy piece sort of through her pupil,” explains PJ, Dania’...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Local News Syndicated Local Boston Children's Hospital Cancer Dr. Mallika Marshall Source Type: news
KNOXVILLE, Tenn. - A couple on Dec. 11 filed a complaint in Tennessee federal court seeking damages against Monsanto Co., alleging that it knew that the chemical glyphosate, which is the active ingredient in the herbicide Roundup, could pose "significant risks to human health, including a risk of cancer" yet misrepresented it as safe (Warren Ahrent, et al. v. Monsanto Company, No. 18-65, E.D. Tenn.).
Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News - Category: Medical Law Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Wednesday Afternoon Lecture Series Published and unpublished studies by investigators in the pharmaceutical industry indicate that a disturbingly high number of academic laboratories' reports nominating potential new cancer-drug targets are either non-reproducible or, if reproducible, are not sufficiently robust to form the basis for drug-discovery efforts. The reasons are likely multifactorial, including the ubiquitous use of " down " assays in cancer biology (e.g. decreased cell proliferation, decreased tumor growth, etc.) that incorporate chemical and genetic perturbants that are prone to cause off-target effe...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
We are thrilled that our recently published article addressing the heritability of  colorectal cancer (CRC) in twins1 has spurred broader discussion about screening practices in families affected by the disease. In an editorial accompanying our article, Sammader and Curtin2 elaborated on the burden of CRC among first-degree relatives of probands and cited additional evidence tha t screening may prove especially effective for individuals with a family history. Matuchansky has now further recapitulated existing literature that suggests that familial risk may be higher for siblings than for parents or children of probands.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Conclusions:Children with ESLD and malnutrition who have failed enteral feeding may benefit from PN to improve and/or resolve malnutrition before liver transplant. Objective: Malnutrition is a common complication of end-stage liver disease (ESLD) associated with poor liver transplant outcomes. Nasogastric feeds are used for nutritional supplementation, but some patients remain malnourished. Parenteral nutrition (PN) can be effective, but has potential complications. The primary objective was to evaluate the effect of PN on anthropometric measures in children with ESLD awaiting liver transplant. Secondary objectives wer...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
Conclusions:In this retrospective pilot study, PMSA was significantly lower in children with ESLD compared with healthy age- and gender-matched controls. Because this finding was independent of growth in ESLD subjects, PMSA may represent a novel objective nutritional biomarker in children with advanced liver disease. Background: Sarcopenia, reflected by decreased psoas muscle surface area (PMSA), has been identified as a novel and independent predictor of wait-list mortality and outcomes in adult liver transplantation (LT). We hypothesized that children with end-stage liver disease (ESLD) would have smaller PMSA than h...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
Conclusions:Pediatric PSC patients cared for at a regional referral center had relatively mild disease compared with previously published reports, with low MRCP stricture scores despite significant liver fibrosis. Liver tests at presentation did not correlate with MRCP stricture score or liver fibrosis stage, suggesting the need for future studies to identify potential biomarkers of disease severity. Objectives: The aims of this study were to characterize pediatric primary sclerosing cholangitis (PSC) at a regional referral-based institution, including scoring of biliary stricturing and liver fibrosis and correlation a...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
This study shows that while any single specific bone marrow failure/myelodysplastic syndrome genetic disorder is rare, screening for these disorders in aggregate identifies a significant subset of patients with inherited bone marrow failure/myelodysplastic syndrome. PMID: 27418648 [PubMed - in process]
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
More News: Anemia | Aplastic Anemia | Cancer | Cancer & Oncology | Cancer in Adolescents | Cancer in Young Adults | Children | Genetics | Hematology | Myelodysplastic Syndrome | Pediatrics | Study | Transplants