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Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients.

This study shows that while any single specific bone marrow failure/myelodysplastic syndrome genetic disorder is rare, screening for these disorders in aggregate identifies a significant subset of patients with inherited bone marrow failure/myelodysplastic syndrome. PMID: 27418648 [PubMed - as supplied by publisher]
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research

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Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
In this study, chitosan was used to coat the adsorbent for preventing the leakage of Zn2+ loaded. Meanwhile, freeze-drying method was used to enhance adsorption capacity of Zn2+-loaded cellulose beads for testosterone. The results indicate that after the adsorbent was coated by 0.02% chitosan solution, the highest adsorption percentage reached 48%, during adsorption, the Zn2+ concentration in plasma did not increase; the adsorption capacity of the adsorbent can be significantly enhanced by freeze-drying. The results may be caused by porosity of the adsorbent enlarged via freeze-drying and improved stability by coating with...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
BOWEL cancer symptoms include stomach pain, a change in bowel habits, and finding blood in your stool. You could reveal your risk of the cancer by checking your poo after using the toilet. Should a healthy poo sink or float?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Battino José L. Quiles Periodontal disease, a relevant public health problem worldwide, is generally considered a common pathology of elderly people. In this respect, there is agreement about that nutritional status may be a modifying factor in the progression and healing of the periodontal tissues. Vitamins have been recommended as nutraceuticals for prevention and treatment of some pathological conditions, such as cardiovascular diseases, obesity or cancer. Thus, a systematic approach to determining how the different vitamin type could ameliorate periodontal risks or improve periodontal health is necessary t...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Conclusions RAPN in the setting of select cT2 renal masses can safely be performed with acceptable outcomes. Further studies are warranted to corroborate our findings and to better define the role of robotic nephron sparing for this challenging indication. Patient summary This report shows that robotic surgery can be used for safe removal of a large renal tumor in a minimally invasive fashion, maximizing preservation of renal function, and without compromising cancer control. This large multicenter experience suggests that robot-assisted partial nephrectomy for clinical T2 renal masses is feasible, it offers good surgical ...
Source: European Urology - Category: Urology & Nephrology Source Type: research
AbstractThe Ontario Breast Screening Program for women with a genetic predisposition to breast cancer is one of the first international models of a government-funded public health service that offers systematic genetic screening to women at a high risk of breast cancer. However, since the implementation of the program in 2011, enrolment rates have been lower than anticipated. Whilst there may be several reasons for this to happen, it does call into consideration the ‘inverse equity law’, whereby the more advantaged in society are the first to participate and benefit from universal health services. An outcome of...
Source: Journal of Community Genetics - Category: Genetics & Stem Cells Source Type: research
Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): Yiwen Li, Huailin Yang, Jiuxu Yao, Haiyang Yu, Xin Chen, Peng Zhang, Chunsheng Xiao An amphiphilic biodegradable prodrug (PLG-g-mPEG/CPT) was synthesized by conjugating disulfide-containing camptothecin (CPT) to poly(L-glutamic acid)-graft-methoxy poly(ethylene glycol) (PLG-g-mPEG) through esterification reaction. The amphiphilic prodrugs could self-assemble into micellar nanoparticles and encapsulate doxorubicin (DOX) in aqueous solution at pH 7.4. The treatment of the nanoparticles with reducing glutathione (GSH) at c...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 19 May 2018 Source:Seminars in Cancer Biology Author(s): George Cyriac, Leena Gandhi Immune checkpoint inhibition with anti-PD-1 therapy has been notably successful in non-small cell lung cancer (NSCLC) and changed standard practice in multiple settings. However, despite some durable benefits seen, the majority of unselected patients with NSCLC fail to respond to checkpoint inhibitors. Patient selection is crucial and will become even more important in the development of combination therapies with immune checkpoint inhibitors. PD-L1 expression by immunohistochemistry (IHC) has emerged as...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 19 May 2018 Source:Chinese Chemical Letters Author(s): Shasha Ying, Shubo Du, Jia Dong, Bi Xuan Ng, Chengwu Zhang, Lin Li, Jingyan Ge, Qing Zhu Wortmannin, a known inhibitor of phosphoinositide 3-kinases (PI3Ks), their low selectivity and high toxicity is still problematic and less is known about their effects on PI3Ks in cellular systems. Hence, we have synthesized a series of multifunctional wortmannin probes with the ability to self-activate, by installing a clickable handle at C11 site, and secondary amine and cancer-targeting moiety at C20 site, respectively. MTT assay first confirm...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
This study shows that while any single specific bone marrow failure/myelodysplastic syndrome genetic disorder is rare, screening for these disorders in aggregate identifies a significant subset of patients with inherited bone marrow failure/myelodysplastic syndrome. PMID: 27418648 [PubMed - in process]
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
More News: Anemia | Aplastic Anemia | Cancer | Cancer & Oncology | Cancer in Adolescents | Cancer in Young Adults | Children | Genetics | Hematology | Myelodysplastic Syndrome | Pediatrics | Study | Transplants