Diagnostic power of 64-channel multidetector CT with three dimensional images in evaluating and staging gastric lymphoma
Conclusion MDCT with 3D images provides valuable results regarding diagnosis and staging of gastric lymphomas.
Basel, 25 February 2020 – Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the US Food and Drug Administration (FDA) has accepted the company’s Biologics License Application (BLA) for the fixed-dose combination (FDC) of Perjeta® (pertuzumab) and Herceptin® (trastuzumab) with hyaluronidase, administered by subc utaneous (SC) injection in combination with intravenous (IV) chemotherapy, for the treatment of eligible patients with HER2-positive breast cancer. The BLA for the FDC is based on results from the phase III FeDeriCa study, which demonstrated non-inferior levels of Perjeta in the blood (phar...
ConclusionsA small subset of PSPD patients may experience response after an initial progression. Assessment of the current strategy for immune ‐related response evaluations may require further attention.
Conditions: Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma; Follicular Lymphoma; Marginal Zone Lymphoma; Mantle Cell Lymphoma; Diffuse Large B Cell Lymphoma; Advanced Solid Tumor; Non-small Cell Lung Cancer; Metastatic Melanoma Interventions: Drug: BGB-10188; Drug: Zanubrutinib; Drug: Tislelizumab Sponsor: BeiGene Not yet recruiting
Condition: Solid Tumor, Non-Hodgkin's Lymphoma Interventions: Drug: ATG-019; Combination Product: ATG-019 + Niacin ER Sponsor: Antengene therapeutics corporation Not yet recruiting
ConclusionsCommon clinical variables coupled with vertebral body height are more predictive of first cycle MTX CL than BSA, alternate body size descriptors, and commonly used kidney function equations.
Publication date: April 2020Source: Fish &Shellfish Immunology, Volume 99Author(s): Shujing Liu, Weilin Wang, Wenjing Ge, Xiaojing Lv, Zirong Han, Yinan Li, Lingling Wang, Linsheng SongAbstractThe homeostasis of immune cells during immune response is vital for hosts to defend against invaders. Activating transcription factor 6 (ATF6) is an important transcription factor in the unfolded protein response (UPR) to maintaining cellular homeostasis. In the present study, one ATF6 homologue was identified from Pacific oyster Crassostrea gigas (designated as CgATF6β). The full length cDNA of CgATF6β was of 2645 bp w...
These data, in combination with durable complete responses and overall survival data, suggested that tisagenlecleucel improved health-related quality of life in adult patients with relapsed or refractory diffuse large B-cell lymphoma who respond to treatment.
This study opens new ways to understand underlying causes of lymphoma. The researchers are now interested in finding whether their results can be applied to other types of cancer
CONCLUSIONS: Testing for autoantibodies against both Ro peptides may aim diagnosis, classify clinical manifestations in disease entities and define prognosis in certain autoimmune disorders. A distinct weight could be given to the isolated anti-Ro specificities in the SS classification criteria. PMID: 32083547 [PubMed - as supplied by publisher]
Publication date: Available online 4 February 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Divaya Bhutani, Amer Assal, Markus Y. Mapara, Samantha Prinzing, Suzanne Lentzsch