[Lung cancer screening with thoracic X‑ray and CT : Current situation].
[Lung cancer screening with thoracic X‑ray and CT : Current situation].
Radiologe. 2016 Jul 13;
Authors: von Stackelberg O, Kauczor HU
Abstract
CLINICAL/METHODICAL ISSUE: Attempts at the early detection of lung cancer using imaging methods began as far back as the 1950s.
STANDARD RADIOLOGICAL METHODS: Several studies attempted to demonstrate a reduction of lung cancer mortality by chest radiography screening but all were unsuccessful.
METHODICAL INNOVATIONS: Even the first small screening studies using computed tomography (CT) could not demonstrate a reduction in lung cancer-specific mortality until in 2011 the results of the largest randomized controlled low-dose CT screening study in the USA (NLST) were published. The NLST results could show a significant 20 % reduction of lung cancer mortality in elderly and heavy smokers using CT.
PERFORMANCE: Confirmation of the NLST results are urgently needed so that the data of the largest European study (NELSON) are eagerly awaited.
ACHIEVEMENTS: Pooled with the data from several smaller European studies these results will provide important information and evidence for the establishment of future CT screening programs in Europe.
PRACTICAL RECOMMENDATIONS: Randomized controlled trials are the basis of evidence-based medicine; therefore, the positive results of the methodologically very good NLST study cannot be ignored, even if it is the only such s...
Source: Der Radiologe - Category: Radiology Authors: von Stackelberg O, Kauczor HU Tags: Radiologe Source Type: research
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