Opioid Drugs for Mental Anguish: Basic Research and Clinical Trials

The prescription opioid crisis of overdosing and overprescribing has reached epic proportions, according to the North American media. Just last week, we learned that 91% of patients who survive opioid overdose are prescribed more opioids! The CDC calls it an epidemic, and notes there's been “a 200% increase in the rate of overdose deaths involving opioid pain relievers and heroin.” A recent paper in the Annual Review of Public Health labels it a “public health crisis” and proposes “interventions to address the epidemic of opioid addiction” (Kolodny et al., 2015).In the midst of this public and professional outcry, why on earth would anyone recommend opioid drugs as a treatment for severe depression and suicidal ideation??Let's revisit the questions posed in my previous post: Does the pain of mental anguish rely on the same neural machinery as physical pain?     Can we treat these dreaded ailments with the same medications? The opioid-for-depression proponents would answer both of those questions in the affirmative,1 with some qualifications. First off, the actual medication in question (and its dose) is different from the typically abused opiate / opioid drug. As far as I can tell, no one is clamoring for narcotic analgesics like OxyContin and Vicodin to be used as antidepressants.In his 2008 paper on the Psychotherapeutic Benefits of Opioid Agonist Therapy, Dr. Peter L. Tenore reviewred the history of the Opium Cure and...
Source: The Neurocritic - Category: Neuroscience Authors: Source Type: blogs

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INTRODUCTION: The use of tobacco, alcohol and other drugs usually starts during the adolescence. In Argentina, it happens at an increasingly younger age. The purpose of the study was to explore social and personal factors that can predict the start of cons...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
The study examined social variables and suicidal behaviour tendency among university students in Akwa Ibom State. Two purposes, research questions and hypotheses apiece were formulated to guide the study. The researchers adopted the descriptive survey desi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
This study sets out to explore whether emotional intelligence has a mediating role in the relationship between fear of missing out in social environments (FoMO) and the depression among university students. The study group consisted of 370 (200 female and ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
CONCLUSION: A significant proportion of patients with LDL-C≥250 mg/dL were not taking lipid-lowering drugs. Similar with many other studies, diagnosis and treatment rates of FH patients were very low in our study. Further national studies are required to increase awareness of the disease in both physicians and patients. PMID: 32744105 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Do you guys think there is enough volume to support an outpatient interventional cancer pain &cancer rehab practice? I will be starting my PM&R residency training at one of the top programs in the country after this academic year (am an prelim medicine intern right now). And I ultimately want to help cancer survivors. I think with the continuing improvements with cancer treatments (most recently with immunotherapy), cancer will be/is a chronic disease with debilitating side effects that... cancer pain only practice
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Perioperative Use of Gabapentinoids for the Management of Postoperative Acute Pain:A Systematic Review and Meta-analysis | Anesthesiology | ASA Publications In this new meta-analysis in this months’ Anesthesiology, the use of these drugs is very much called into question. Will this change your practice?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Anesthesiology Source Type: forums
Conclusions Drug and alcohol education strategies must be more explicit regarding harm across all drug types, regardless of legal status or perceived social acceptability. Prevention services would benefit from including lived realities from young people's varied, and changing, substance-use trajectories. Peer involvement in the design of preventive strategies (and involvement in participatory research to identify felt needs) is paramount to ensure teachings are grounded in a young person's social context and lived realities. So what? This study provides information to guide development of appropriate and authentic drug an...
Source: Health Promotion Journal of Australia - Category: International Medicine & Public Health Tags: Health Promot J Austr Source Type: research
Conclusions: In this cohort, racial/ethnic differences in sleep quality were common. PMID: 32742152 [PubMed - in process]
Source: Ethnicity and Disease - Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research
Publication date: September 2020Source: Social Science &Medicine, Volume 261Author(s): Vani A. Mathur, Theresa Morris, Kelly McNamara
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 4 August 2020Source: International Journal of PsychophysiologyAuthor(s): Jayne Morriss, Nico Biagi, Helen Dodd
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research
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