Transdermal delivery of Angiotensin Converting Enzyme Inhibitors.

Transdermal delivery of Angiotensin Converting Enzyme Inhibitors.
Eur J Pharm Biopharm. 2014 Mar 20;
Authors: Helal F, Lane ME
Abstract
The Angiotensin Converting Enzyme (ACE) inhibitor class of drugs has been in clinical use since the 1970's for the management of all grades of heart failure, hypertension, diabetic nephropathy and prophylaxis of cardiovascular events. Because of the advantages associated with transdermal delivery compared with oral delivery many researchers have investigated the skin as a portal for administration of ACE inhibitors. This review summarises the various studies reported in the literature describing the development and evaluation of transdermal formulations of ACE inhibitors. Captopril, enalapril maleate, lisinopril dihydrate, perindopril erbumine and trandolapril are the most studied in connection with transdermal preparations. The methodologies reported are considered critically and the limitations of the various skin models used are also highlighted. Finally, opportunities for novel transdermal preparations of ACE inhibitor drugs are discussed with an emphasis on rational formulation design.
PMID: 24657822 [PubMed - as supplied by publisher]

Source: European Journal of Pharmaceutics and Biopharmaceutics - March 20, 2014 Category: Drugs & Pharmacology Authors: Helal F, Lane ME Tags: Eur J Pharm Biopharm Source Type: research