KIR3DL1 Allelic Polymorphism and HLA-B Epitopes Modulate Response to Anti-GD2 Monoclonal Antibody in Patients With Neuroblastoma [Rapid Communication]

Conclusion
We conclude that KIR3LD1 and HLA-B allele combinations can have a prognostic impact on patient survival after treatment with anti-GD2 mAb that relies on NK-ADCC. The survival advantage seen in noninteracting combinations supports the therapeutic disinhibition of individuals with strongly interacting KIR and ligand pairs.

Source: Journal of Clinical Oncology - July 12, 2016 Category: Cancer & Oncology Authors: Forlenza, Boudreau, Zheng, Le Luduec, Chamberlain, Heller, Cheung, Hsu Tags: Neuroblastoma, Rapid Communications, Rapid Communications, Immunology/Immunobiology Source Type: research