Effect of TongXie-YaoFang on Cl(-) and HCO3 (-) Transport in Diarrhea-Predominant Irritable Bowel Syndrome Rats.

Effect of TongXie-YaoFang on Cl(-) and HCO3 (-) Transport in Diarrhea-Predominant Irritable Bowel Syndrome Rats. Evid Based Complement Alternat Med. 2016;2016:7954982 Authors: Lu X, Zhang S, Yang C, Wang Z, Zhao L, Wu Z, Xie J Abstract TongXie-YaoFang (TXYF) can effectively alleviate the symptoms of diarrhea-predominant irritable bowel syndrome (D-IBS) patients. However, the curative mechanism has not been fully clarified. The study was designed to investigate the effect of TXYF on the colonic ion transport induced by serotonin (5-HT) in D-IBS rats. A method of multiple stress (neonatal maternal separation (NMS) combined with restraint stress (RS)) was used to induce the D-IBS model. The model rats were randomly divided into two groups: NMS + RS group and TXYF-formula group, and the normal control (no handling) rats were classified as NH group. In the NMS + RS group, the change of short-circuit current (ΔI sc) induced by 5-HT was lower than that in the NH and TXYF-formula groups. After removing of the extracellular Cl(-) or HCO3 (-) or basolateral Na(+) or blocking the cystic fibrosis transmembrane conductance regulator (CFTR), Na(+)-K(+)-2Cl(-) cotransporter (NKCC), Na(+)-HCO3 (-) cotransporter, Cl(-)/HCO3 (-) exchanger, K(+) channel, or Na(+)/K(+)-ATPase, respectively, there was no difference in 5-HT-induced ΔI sc among the three groups. These data suggest that TXYF can regulate 5-HT-induced Cl(-) and HCO3 (-) secretion, possibly mediated by...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

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Smith Etareri Evivie1,2†, Amro Abdelazez1,3, Bailiang Li1†, Xin Bian4, Wan Li1, Jincheng Du1, Guicheng Huo1* and Fei Liu1 1Key Laboratory of Dairy Science, Ministry of Education, College of Food Sciences, Northeast Agricultural University, Harbin, China 2Food Science and Nutrition Unit, Department of Animal Science, Faculty of Agriculture, University of Benin, Benin City, Nigeria 3Department of Dairy Microbiology, Animal Production Research Institute, Agriculture Research Center, Giza, Egypt 4Department of Food Engineering, Harbin University of Commerce, Harbin, China Foodborne pathogens are a ma...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Blood, saliva, urine, sweat or even ear wax can carry valuable information about an individual’s medical state. Until now, even simpler tests on such bodily fluids had to be carried out at medical facilities, but with the recent uptick in the development of digital diagnostic technologies, more and more solutions appear on the market which enable the patient to do such tests at home. Here we take a look around the bodily fluid business. From bloodletting to digital sweat measurement Blood, yellow bile, black bile, phlegm. Although it doesn’t sound appealing, the ancient Greek already thought that bodily f...
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AbstractPlecanatide, a uroguanylin analog, activates the guanylate cyclase C receptors in the epithelial lining of the gastrointestinal tract in a pH-dependent fashion initiating (1) the conversion of intracellular guanosine triphosphate to cyclic guanosine monophosphate, which increases the activity of the cystic fibrosis transmembrane conductance regulator to increase chloride and bicarbonate secretion into the intestinal lumen and (2) a decrease in activity of the sodium-hydrogen ion exchanger. The resulting ionic shifts cause an increase in lumenal fluid to facilitate digestion. Plecanatide has been approved by the FDA...
Source: Drug Safety - Category: Drugs & Pharmacology Source Type: research
The pooled population prevalence of irritable bowel syndrome (IBS) has been estimated at 11.2%.1 Until the turn of the century, treatment options with convincing evidence of effectiveness were lacking.2 Since then, new therapeutic options have emerged, including intestinal secretagogues for the treatment of IBS with constipation (IBS-C), which accounts for approximately 40% of patients with IBS.3 Secretagogues are agents that increase luminal water content through the activation of chloride secretion by the chloride channel type-2 (lubiprostone), through activation of the guanylate cyclase receptor and the cystic fibrosis ...
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Editorial Source Type: research
Abstract Calprotectin is a calcium- and zinc-binding protein of the S-100 protein family which is mainly found within neutrophils and throughout the human body. The presence of calprotectin in faeces is a consequence of neutrophil migration into the gastrointestinal tissue due to an inflammatory process. Faecal calprotectin concentrations demonstrate good correlation with intestinal inflammation and faecal calprotectin is used as a biomarker in gastrointestinal disorders. Faecal calprotectin is a very sensitive marker for inflammation in the gastrointestinal tract, and useful for the differentiation of inflammator...
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Follow the current debate on “healthcare reform”–which has NOTHING to do with healthcare reform, but healthcare insurance reform, by the way–and you will hear comments about the escalating and uncontrolled cost of healthcare and how people need access to it. What you will NOT hear is that fact that, because the healthcare system fails to deliver genuine health, real health is actually quite easy, straightforward, and inexpensive–nearly free. We achieve a life of being Undoctored, not becoming a profit source for the healthcare industry, not being subjected to the predatory practices of Big P...
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Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research
Abstract AIM: To investigate the pharmacological effect of TongXie-YaoFang (TXYF) formula, a Chinese herbal formula, on Diarrhea-predominant irritable bowel syndrome (D-IBS) rats. METHODS: In a neonatal maternal separation plus restraint stress (NMS + RS) model of D-IBS, male Sprague Dawley rats were randomly divided into two groups (NMS + RS group and TXYF-formula group) with no handlings were used as controls (NH group). Starting from postnatal day 60, rats in TXYF-formula group were administered TXYF-formula (4.92 g/100 g bodyweight) orally twice a day for 14 consecutive days while NH group and NMS + RS gr...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
In the gastrointestinal (GI) tract, abnormalities in secretion, absorption, motility, and sensation have been implicated in functional gastrointestinal disorders (FGIDs). Ion channels play important roles in all these GI functions. Disruptions of ion channels' ability to conduct ions can lead to diseases called ion channelopathies. Channelopathies can result from changes in ion channel biophysical function or expression due to mutations, posttranslational modification, and accessory protein malfunction. Channelopathies are strongly established in the fields of cardiology and neurology, but ion channelopathies are only begi...
Source: AJP: Gastrointestinal and Liver Physiology - Category: Gastroenterology Authors: Tags: MINIREVIEW Source Type: research
Abstract In the gastrointestinal (GI) tract, abnormalities in secretion, absorption, motility and sensation have been implicated in functional gastrointestinal disorders (FGIDs). Ion channels play important roles in all these GI functions. Disruptions of an ion channel's ability to conduct ions can lead to diseases called ion channelopathies. Channelopathies can result from changes in ion channel biophysical function or expression due to mutations, post-translational modification, and accessory protein malfunction. Channelopathies are strongly established in the fields of cardiology and neurology, but ion channelo...
Source: Am J Physiol Gastroi... - Category: Gastroenterology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research
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