The Non-Opioid Abusers
Those of us who live with chronic pain take pain medication, including opioids. There has been quite a bit in the news about the growing opioid epidemic which is killing thousands of Americans. Most of those who die are abusers who overdose. The resulting laws trying to restrict access to opioids causes difficulties for those of us who actually live in chronic pain and need the opioids to function.Could you imagine needing to go back to your doctor's office to pick up a paper prescription to bring to your pharmacy to refill it? That is what happens now. Yes really. Can you imagine being in total pain and having to drive or ride a bus just to get that little piece of paper?The new laws designed to restrict access by drug users have the unintentional effect of making it harder on the people who need them to function. For someone in chronic pain, who has to limit their efforts and make deliberate choices on how to spend their time and efforts, any extra trips are avoided at all costs.So what do we do? We cope. We look for alternate therapies that make life easier for us. I am on opioids but mine come in patch that I apply weekly that gives me a controlled dose of pain medication that is essential for my daily activities. I hope more manufacturers step up and come up with more alternative delivery methods which allow pain relief for those in need but does not allow easy access by abusers.
What impact do antibiotic-related changes of the gut microbiome have on efficacy of immune-checkpoint inhibitors?Annals of Oncology
For patients with life-altering illnesses or anyone just getting older, it helps to roll with the punches and make the best of the here and now.
Men with early stage prostate cancer did not show benefits from a vegetable-rich diet.
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Publication date: Available online 19 January 2020Source: Food Research InternationalAuthor(s): Caiyu Lei, Xiangyi Tang, He Li, Hualei Chen, Shujuan YuAbstractThe grape seed extract (GSE) hybridized with medium-chain saturated fatty acids (decanoic acid) exhibited higher lipophilicity, antioxidant activity, and anti-proliferative activity than its parents. The chemical structures of individual hybridized GSE derivatives were identified as 3'-O-decanoyl catechin, 3′-O-decanoyl epicatechin, 3', 5'-2-O-decanoyl epigallocatechin, and 3', 4', 3'', 5''-4-O-decanoyl epicatechin gallate by HPLC-MS2 and 1H and 13C NMR. For gr...
Women whose periods stop before the age of 40 are at greater risk of diabetes, heart disease, strokes, asthma and breast cancer, the study found. The UK menopause average is 51.
Publication date: 15 April 2020Source: Journal of Molecular Structure, Volume 1206Author(s): Imre Huber, Zsuzsanna Rozmer, Zoltán Gyöngyi, Ferenc Budán, Péter Horváth, Eszter Kiss, Pál PerjésiAbstractThe chemical susceptibility of the β-diketone linker between the two aromatic rings in the structure of curcumin to hydrolysis and metabolism has made it crucial to investigate structurally modified analogs of curcumin without such shortcomings. The synthesis of twenty cyclic C5-curcuminoids is described in this study in order to gain more insight into their anticancer struct...