Reprint of: Immune defense is the primary function associated with the differentially expressed genes in the cochlea following acoustic trauma.

Reprint of: Immune defense is the primary function associated with the differentially expressed genes in the cochlea following acoustic trauma. Hear Res. 2016 Jul 9; Authors: Yang S, Cai Q, Vethanayagam RR, Wang J, Yang W, Hu BH Abstract Our previous RNA-sequencing analysis of the rat cochlear genes identified multiple biological processes and molecular pathways in the cochlear response to acoustic overstimulation. However, the biological processes and molecular pathways that are common to other species have not been documented. The identification of these common stress processes is pivotal for a better understanding of the essential response of the cochlea to acoustic injury. Here, we compared the RNA-sequencing data collected from mice and rats that sustained a similar, but not identical, acoustic injury. The transcriptome analysis of cochlear genes identified the differentially expressed genes in the mouse and rat samples. Bioinformatics analysis revealed a marked similarity in the changes in the biological processes between the two species, although the differentially expressed genes did not overlap well. The common processes associated with the differentially expressed genes are primarily associated with immunity and inflammation, which include the immune response, response to wounding, the defense response, chemotaxis and inflammatory responses. Moreover, analysis of the molecular pathways showed considerable overlap between th...
Source: Hearing Research - Category: Audiology Authors: Tags: Hear Res Source Type: research