Targeting Aurora A kinase with Alisertib (ALS) Induces Autophagy and Cell Cycle Arrest and Increases Chemosensitivity in Hepatoblastoma HepG2 Cells.

CONCLUSIONS: ALS exerted anticancer effects in both monotherapy and combinational therapy in HepG2 cells. Autophagy inhibition may promote the anticancer effect of ALS and sensitize the chemotherapy in HepG2 cells.
PMID: 27396604 [PubMed - as supplied by publisher]

Source: Current Cancer Drug Targets - June 29, 2016 Category: Cancer & Oncology Authors: Zhu Q, Yu X, Zhou ZW, Zhou C, Chen XW Tags: Curr Cancer Drug Targets Source Type: research