Identification of Helminths and their Intermediate Hosts at High Latitudes

Funding Opportunity ID: 285973 Opportunity Number: USGS-16-FA-0307 Opportunity Title: Identification of Helminths and their Intermediate Hosts at High LatitudesOpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementCategory of Funding Activity: Natural ResourcesCategory Explanation: CFDA Number(s): 15.808Eligible Applicants: Private institutions of higher educationAdditional Information on Eligibility: Agency Code: DOI-USGS1Agency Name: Department of the InteriorGeological SurveyPosted Date: Jul 11, 2016Close Date: Jul 25, 2016Last Updated Date: Jul 11, 2016Award Ceiling: $25,000Award Floor: $25,000Estimated Total Program Funding: Expected Number of Awards: 1Description: Notice of Intent to Award to Sam Houston State University for Identification of Helminths and their Intermediate Hosts at High Latitudes. Objectives: (1) Identify intermediate hosts (i.e., specific aquatic invertebrates) of parasites known to infect hosts in the Alaskan Arctic and subarctic. (2) Evaluate the detection probability of helminths in waterfowl fecal samples to evaluate non-lethal method of helminth sampling. (3) Genetically test fecal samples of marked waterfowl for the presence of previously identified helminths to evaluate potential fitness consequences to hosts of infection. Version: Synopsis 1
Source: Grants.gov - Category: Research Tags: Natural Resources Source Type: funding

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Parasites genes prepare it for the unexpected, but could be exploited to fight the disease More at https://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=299535&WT.mc_id=USNSF_1 This is a Research News item.
Source: NSF Discoveries - Category: Science Source Type: research
In conclusion, the serodiagnostic assays evaluated in this study are useful for the detection of ascarid infections in chickens.Graphical abstract
Source: Parasitology International - Category: Parasitology Source Type: research
Abstract Folates are essential biomolecules required to carry out many crucial processes in leishmania parasite. Dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine reductase 1 (PTR1) involved in folate biosynthesis in leishmania have been established as suitable targets for development of chemotherapy against leishmaniasis. In the present study, various computational tools such as homology modelling, pharmacophore modelling, docking, molecular dynamics and molecular mechanics have been employed to design dual DHFR-TS and PTR1 inhibitors. Two designed molecules, i.e. 2-(4-((4-nitrobenzyl)oxy)pheny...
Source: SAR and QSAR in Environmental Research - Category: Environmental Health Authors: Tags: SAR QSAR Environ Res Source Type: research
Publication date: Available online 8 November 2019Source: Protein Expression and PurificationAuthor(s): B.O. Araujo-Montoya, M.R. Senger, B.F. Gomes, G. Harris, R.J. Owens, F.P. Silva-JrAbstractSchistosomes express a variety of aspartyl proteases (APs) with distinct roles in the helminth pathophysiology, among which degradation of host haemoglobin is key, since it is the main amino acid source for these parasites. A cathepsin D-like AP from Schistosoma mansoni (SmCD1) has been used as a model enzyme for vaccine and drug development studies in schistosomes and yet a reliable expression system for readily producing the recom...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Publication date: Available online 9 November 2019Source: Molecular and Biochemical ParasitologyAuthor(s): Víctor Caña-Bozada, F. Neptalí Morales-Serna, Alejandra García-Gasca, Raúl Llera-Herrera, Emma J. Fajer-ÁvilaAbstractATP-Binding Cassette (ABC) transporters are proteins that actively mediate the transport of a wide variety of molecules, including drugs. Thus, in parasitology, ABC transporters have gained attention as potential targets for therapeutic drugs. Among the parasitic Platyhelminthes, ABC transporters have been identified and classified in a few species of Trematoda ...
Source: Molecular and Biochemical Parasitology - Category: Parasitology Source Type: research
In conclusion, this reduced establishment rate was associated with an increased production of eggs by the female parasites and suggested a phenomenon of density-dependent prolificacy of H. contortus probably inherent to the fitness of the parasite population.
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Publication date: Available online 8 November 2019Source: MicronAuthor(s): Isaac Filipe Moreira Konig, Marcos Vinícius Silva de Oliveira, Raquel Romano Palmeira Gonçalves, Ana Paula Peconick, Sérgio Scherrer Thomasi, Luís Adriano Anholeto, José Ribamar Lima-de-Souza, Maria Izabel Camargo-Mathias, Rafael Neodini RemedioAbstractRhipicephalus sanguineus sensu lato (s. l.) ticks are targets of acaricidal treatments due to their great veterinary and medical importance. Acetylcarvacrol stands out as a promising acaricidal substance for its increased biocidal activity and stability. Additionally...
Source: Micron - Category: Biology Source Type: research
Publication date: Available online 8 November 2019Source: Pesticide Biochemistry and PhysiologyAuthor(s): Elodie Peghaire, Anne Moné, Frédéric Delbac, Didier Debroas, Frédérique Chaucheyras-Durand, Hicham El AlaouiAbstractHoneybees ensure a key ecosystemic service by pollinating many agricultural crops and wild plants. However, since few decades, managed bee colonies have declined worldwide. This phenomenon is considered to be multifactorial, with a strong emphasis on both parasites and pesticides. Infection by the parasite Nosema ceranae and exposure to pesticides can contribute to adver...
Source: Pesticide Biochemistry and Physiology - Category: Biochemistry Source Type: research
AbstractCystic echinococcosis is a potential zoonotic helminthic disease affect a broad spectrum of mammals including humans worldwide. The economic impact of the disease interestingly requires updated gathering information on the prevalence in slaughtered animals. Accordingly, in the current study, 573 camels, 4300 sheep, and 1235 pigs were surveyed in four Egyptian municipal abattoirs. Among those, 62 (10.82%) camels, 33 (0.77%) sheep and 3 (0.24%) pigs had cystic echinococcosis in lungs, livers and spleen. The diversity of cysts revealed that positive-cystic echinococcosis animals from all species were detected in El-Ba...
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
In conclusion, all extracts and petroleum ether extracts of the two plants have great potential to be developed as a novel acaricidal for controlling eggs and nymphs ofH. dromedarii, respectively.
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
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