There are three kinds of pedestrian – which are you?

You know that situation where you're walking across a train station concourse or a park and there's another person walking on a different trajectory that means if you both hold your course and speed, you're going to collide? Are you the kind of person who assumes the other guy will give way, or are you the polite one who slows down and lets the other person cross your path?A new study in the Journal of Experimental Psychology: Human Perception and Performance recreated this scenario by pairing up 20 participants – a mix of young men and women – and having one person in each pair walk diagonally from one corner of the room to the other, while the other person walked the other diagonal (see schematic below). On each of many trials, both participants in each pair began walking on a starting signal and they were asked to make sure they didn't collide, all without communication with each other. The participants also filled out personality questionnaires and the researchers recorded their heights, weight and age.The participants tended to show a consistent pattern of behaviour across trials: roughly a quarter were more inclined to give way to avoid colliding; a quarter usually crossed the potential interception point first, making the other person give way; while the others showed a mixture of behaviours. But crucially, neither personality traits, gender, age, height or weight were related to what kind of collision avoidance strategy the participants tended to use. So i...
Source: BPS RESEARCH DIGEST - Category: Psychiatry & Psychology Authors: Source Type: blogs

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In this study, we found that TLR1/TLR2 expression predicted favorable prognosis of lung cancer patients. In the related mice tumor model, TLR1/TLR2 activation by synthetic bacterial lipoprotein (BLP), a TLR1/2 agonist, greatly inhibited tumor growth and selectively decreased monocytic MDSCs (M-MDSCs). Furthermore, BLP treatment redirected M-MDSC differentiation towards M1 macrophage through JNK pathway, and thus blocked the suppressive activity of M-MDSCs in a TLR2-dependent manner. Therefore, our data demonstrated that TLR2 could be a promising biomarker and a potential immunotherapeutic target for lung cancer.
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Publication date: August 2019Source: Molecular Immunology, Volume 112Author(s): Elizabeth A. Bemis, Jill M. Norris, Jennifer Seifert, Ashley Frazer-Abel, Yuko Okamoto, Marie L. Feser, M. Kristen Demoruelle, Kevin D. Deane, Nirmal K. Banda, V. Michael HolersAbstractRheumatoid arthritis (RA) is a complex autoimmune disease with an etiology that is not yet well understood, disproportionally affects women and also varies in incidence and prevalence by population. The presence of anti-citrullinated protein antibodies (ACPA) is a highly specific biomarker for the diagnosis of clinically apparent RA. ACPA are also present in the ...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 14 June 2019Source: Analytic Methods in Accident ResearchAuthor(s): Lai Zheng, Tarek Sayed, Mohamed EssaAbstractA Bayesian hierarchical modeling (BHM) approach is used to model non-stationary traffic conflict extremes of different sites together for crash estimation. The hierarchical structure has three layers, a data layer that is modeled with a generalized extreme value (GEV) distribution, a latent Gaussian process layer that relates parameters of GEV to covariates and the unobserved heterogeneity, and a prior layer with prior distributions to characterize the latent process. The propos...
Source: Analytic Methods in Accident Research - Category: Accident Prevention Source Type: research
Publication date: Available online 14 June 2019Source: Stem Cell ResearchAuthor(s): Nupur Bhargava, Shashank Jaitly, Sangam Giri Goswami, Suman Jain, Debojyoti Chakraborty, Sivaprakash RamalingamAbstractSickle cell disease (SCD) is an autosomal recessive disorder caused by a mutation in β-globin (HBB) gene. We have generated an induced pluripotent stem cell (iPSC) line, IGIBi001-A from an Indian sickle cell patient with a homozygous HBB gene mutation using Sendai virus reprogramming system. Characterization of IGIBi001-A showed that these iPSCs are transgene-free and expressed pluripotent stem cell markers. They had a...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 14 June 2019Source: Stem Cell ResearchAuthor(s): Nutnicha Tantarungsee, Zaukir Bostan Ali, Rungtip Soi-ampornkul, Chuda Rujitharanawong, Chanika Subchookul, Alisa Ritthaphai, Bootsakorn Boonkaew, Methichit Wattanapanitch, Kanchalit Thanomkitti, Daranporn Triwongwaranat, Chinnavuth Vatanashevanopakorn, Rattapon ThuangtongAbstractAn induced pluripotent stem cell (iPSC) line, MUSIi010-A, was established by Sendai virus (SeV) transduction of scalp fibroblasts from a 59-year-old male with androgenetic alopecia (AGA). Pluripotency of the iPSC line was verified by immunofluorescence staining of ...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Authors: Malergue MC, Ohanessian A, Zannis K, Bruneval P, Ennezat PV PMID: 31199198 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
This report could be used to provide guidance for both practical and economical approaches. PMID: 31190617 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Authors: Lee JH, Nam JH, Park JS, Lee DH PMID: 31190481 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
CONCLUSIONS: These data provide the current PCI practice pattern with the use of FFR and IVUS in intermediate lesion. More common use of FFR for intermediate lesion should be encouraged. PMID: 31190480 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
CONCLUSIONS: Separate examination of control rates demonstrated different sex- and age-differential trends, which would have been overlooked in combined control rates. PMID: 31190479 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
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