Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5- b ]pyridine-2-yl)anilide

Conclusion These findings clearly demonstrate perturbation of ceramide metabolism by OXPA and indicate that the sphingolipid pathway is a promising drug target in T. brucei.

http://link.springer.com/10.1007/s11306-016-1062-1

Source: Metabolomics - July 8, 2016 Category: Biology Source Type: research