Growth hormone, insulin-like growth factor system and carcinogenesis.

Growth hormone, insulin-like growth factor system and carcinogenesis. Endokrynol Pol. 2016 Jul 8; Authors: Boguszewski CL, Boguszewski MC, Kopchick JJ Abstract The growth hormone (GH) and insulin-like growth factor (IGF) system plays an important role in the regulation of cell proliferation, differentiation, apoptosis and angiogenesis. In terms of cell cycle regulation, the GH-IGF system induces signaling pathways for cell growth that compete with other signaling systems that result in cell death; thus the final effect of these opposed forces is critical for normal and abnormal cell growth. The association of GH-IGF system with carcinogenesis has long been hypothesized mainly based on in vitro studies and the use of a variety of animal models of human cancer, and also on epidemiological and clinical evidence in humans. While ample experimental evidence supports a role of GH-IGF system in tumor promotion and progression, with several of its components being currently tested as central targets for cancer therapy, the strength of evidence from patients with acromegaly, GH deficiency or treated with GH is much weaker. In this review, we will attempt to consolidate this data. PMID: 27387246 [PubMed - as supplied by publisher]
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research