NYU’s Bluestone Center Awarded $1.2M from NIH to Investigate Gene Delivery for the Treatment of Oral Cancer Pain

Proposed studies will test the effectiveness of a novel, non-viral gene delivery method developed by Drs. Brian Schmidt and Seiichi Yamano in treating cancer painThe National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health (NIH), has awarded Drs. Brian Schmidt and Seiichi Yamano a $1.2M (3-year) grant to test whether their non-viral gene delivery method can effectively and safely treat oral cancer pain.Quality of life for oral cancer patients can be dismal. “Most of my oral cancer patients have severe pain,” says Brian L. Schmidt, DDS, MD, PhD, professor in the Department of Oral and Maxillofacial Surgery at New York University College of Dentistry (NYU Dentistry) and director of NYU’s Bluestone Center for Clinical Research and of the NYU Oral Cancer Center. “A recent study revealed that oral cancer pain is often more severe than pain from any other type of cancer.” Due to their severe pain, oral cancer patients have difficulty eating, drinking, or talking, leaving doctors with little or no choice other than to prescribe high doses of opioid medications. “The clinical challenge of treating oral cancer pain is then compounded by the off-target effects produced by pharmacological agents which lack anatomical specificity,” notes Dr. Schmidt, “since high opioid doses generate unwanted side effects that create additional unintended suffering for the patient.” “Gene therapy ...
Source: Dental Technology Blog - Category: Dentistry Source Type: news

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(JAMA Network) An ultrarestrictive opioid prescribing strategy was associated with a reduction in the number of pills dispensed in a study of patients having surgery   for gynecologic cancer, without changes in postoperative pain scores, complications or increases in prescription refill requests. Under the protocol,   patients having ambulatory or minimally invasive surgery weren't prescribed opioids at discharge unless they required more than five doses of oral or intravenous opioids while in the hospital.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionsThe pregabalin suppositories prepared in this study may be applicable for pain control for terminally cancer ill patients with oral feeding difficulties.
Source: Journal of Pharmacy and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Research Paper Source Type: research
CONCLUSIONS:: Honey can be used for a variety of otolaryngology conditions. The highest quality meta-analyses support oral honey for prevention and treatment of oral mucositis in cancer patients, cough associated with upper respiratory infection in children, and pain control after tonsillectomy. Further research will likely justify broader applications. PMID: 30501505 [PubMed - as supplied by publisher]
Source: The Annals of Otology, Rhinology, and Laryngology - Category: ENT & OMF Authors: Tags: Ann Otol Rhinol Laryngol Source Type: research
This study was done to evaluate the therapeutic benefit of Placentrex in the management of oral mucositis seen in oral cancer patients undergoing treatment with concurrent chemoradiation. Methodology: This study was carried out, as a retrospective analysis, on oral cancer patients undergoing concurrent chemoradiation with weekly Cisplatin regimen treated between Oct 2015 and July 2017. All the patients received 2ml of Inj Placentrex, once daily administered intramuscularly for 4 weeks, NSAIDs, topical analgesics, and mouth wash as treatment for oral mucositis. The results were compared with a historical control group of 40...
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Conclusions: LARR was associated with significantly reduced blood loss, quicker resumption of oral intake, earlier return of gastrointestinal function, and shorter length of hospital stay at the expense of significantly longer operating time. Postoperative morbidity and mortality and analgesia requirement for both these groups were comparable. LARR seems to be a safe and effective alternative to ORR; however, it needs to be performed in established colorectal units with experienced laparoscopic surgeons.
Source: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques - Category: Surgery Tags: Review Articles Source Type: research
Abstract Crohn's disease is a chronic inflammatory condition that affects the gastrointestinal tract. It can cause lesions from mouth to anus and may result in extraintestinal complications. The prevalence of Crohn's disease is increasing in adults and children. Genetic predispositions to Crohn's disease have been identified, and specific environmental factors have been associated with its development. Common presenting symptoms include diarrhea, abdominal pain, rectal bleeding, fever, weight loss, and fatigue. Physical examination should identify unstable patients requiring immediate care, include an anorectal ex...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
Surgery is the main treatment for oral cancer. Postoperative symptoms often cause structural defects that affect oral intake and physical function, and demotivate patients from complying with treatment.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
Mixed-medication mouth rinses are commonly used for oral pain and inflammation that accompany some cancer treatments. Should they be?Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Publication date: Available online 22 November 2018Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): J. Hoole, D.A. Mitchell, A.B. Smith, A. KanatasAbstractPatient-reported outcomes are increasingly used by clinical teams as indicators of quality when assessing treatment after a diagnosis of head and neck cancer. About a third of patients report reduced sexual interest or enjoyment after such treatment but, despite that, there is no questionnaire about intimacy that has been developed specifically for them. The aim of this study was to develop such a questionnaire, to gain an indication of the relative in...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Abstract BACKGROUND: A majority of patients with abdominal cancer report intractable abdominal pain as their disease progresses. For intractable abdominal pain related to malignancy, celiac plexus block can provide relief and reduce the use of oral opioids, helping to improve quality of life. OBJECTIVES: The aim of this article is to explore the feasibility and effectiveness of celiac plexus block as a pain management option for patients with late-stage abdominal cancer. METHODS: A literature review of articles about pain in late-stage patients with cancer, with a focus on abdominal pain, pain management...
Source: Clinical Journal of Oncology Nursing - Category: Nursing Authors: Tags: Clin J Oncol Nurs Source Type: research
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