NYU’s Bluestone Center Awarded $1.2M from NIH to Investigate Gene Delivery for the Treatment of Oral Cancer Pain

Proposed studies will test the effectiveness of a novel, non-viral gene delivery method developed by Drs. Brian Schmidt and Seiichi Yamano in treating cancer painThe National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health (NIH), has awarded Drs. Brian Schmidt and Seiichi Yamano a $1.2M (3-year) grant to test whether their non-viral gene delivery method can effectively and safely treat oral cancer pain.Quality of life for oral cancer patients can be dismal. “Most of my oral cancer patients have severe pain,” says Brian L. Schmidt, DDS, MD, PhD, professor in the Department of Oral and Maxillofacial Surgery at New York University College of Dentistry (NYU Dentistry) and director of NYU’s Bluestone Center for Clinical Research and of the NYU Oral Cancer Center. “A recent study revealed that oral cancer pain is often more severe than pain from any other type of cancer.” Due to their severe pain, oral cancer patients have difficulty eating, drinking, or talking, leaving doctors with little or no choice other than to prescribe high doses of opioid medications. “The clinical challenge of treating oral cancer pain is then compounded by the off-target effects produced by pharmacological agents which lack anatomical specificity,” notes Dr. Schmidt, “since high opioid doses generate unwanted side effects that create additional unintended suffering for the patient.” “Gene therapy ...
Source: Dental Technology Blog - Category: Dentistry Source Type: news

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te Most patients with cancer pain can be managed with relatively simple methods using oral analgesics at relatively low doses, even for prolonged periods of time. However, in some clinical conditions pain may be more difficult to manage. Various factors can interfere with a desirable and favorable analgesic response. Data from several studies assessing factors of negative pain prognosis have indicated that neuropathic pain, incident pain, psychological distress, opioid addiction, and baseline pain intensity were associated with more difficult pain control. In this narrative review, the main factors that make the therap...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Perspective Source Type: research
Conclusion Transcutaneous electrical nerve stimulation improves pain in HNC patients receiving radiation but not function or pain with function relative to placebo or no TENS. Implications for Practice Transcutaneous electrical nerve stimulation may be a viable tool for radiation-induced HNC pain to complement pharmacologic approaches. This nonpharmacologic intervention could decrease the debilitating effects of radiation and analgesics, and improve quality of life. Clinical trials should examine the effects and safety of repeated, daily TENS in HNC patients receiving radiation.
Source: Cancer Nursing - Category: Nursing Tags: ARTICLES Source Type: research
Oral rinse containing doxepin or the combination of diphenhydramine, lidocaine, and antacid may help reduce oral mucositis-related pain in head and neck cancer patients.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Munch a bit of habanero pepper or hot-sauce-soaked jambalaya, and you’ll notice a tingling numbness in your mouth followed by a burning sensation. If that burning sensation is sufficiently strong, your nose and eyes will start to run, and your mouth and throat will start to generate mucus. You may not be able to feel it, but your stomach and parts of your intestine will also start secreting excess fluid, says Dr. Brett Comer, a surgeon and ear, nose, and throat specialist at the University of Kentucky College of Medicine. Why does all this happen? Like spraying water on a filthy car, your body turns on the waterworks...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Diet/Nutrition Source Type: news
In conclusion, we identified a novel Bcl-2 inhibitor by QSAR screening, which exerted significant cytotoxic activity in breast cancer cells through inducing mitochondria-mediated apoptosis. Introduction Apoptosis is a process of cellular suicide through which unwanted or unhealthy cells are eliminated during organism development or cellular stress (Reed, 2002; Fernald and Kurokawa, 2013). Deregulated apoptosis is a characteristic of cancers (Doi et al., 2012; Roizen, 2012). The B-cell lymphoma-2 (Bcl-2) family is composed of pro- and anti-apoptotic proteins, plays pivotal role in the mitochondrial pathway of apoptosi...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
(Mayo Clinic) 'Magic mouthwash,' an oral rinse containing diphenhydramine, lidocaine and antacids, significantly reduced pain from oral mucositis, mouth sores, in patients receiving radiation therapy for cancers of the head and neck when compared to plaecbo. These were the findings of a multi-institution, randomized, double-blind, placebo-controlled, phase III clinical trial, led by Robert Miller, M.D., an emeritus Mayo Clinic radiation oncologist. Dr. Miller and his colleagues published their findings on Tuesday, April 16, in JAMA.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Oral mucositis is a significant complication of cancer therapy because of the associated pain and negative effects on the ability to eat, drink, and swallow and on the quality of life. Furthermore, oral mucositis increases the risk of systemic infection, and may interrupt cancer therapy. Oral mucositis manifests as erosions or ulcerations of the nonkeratinized oral mucosa, and its course depends on the form of cancer therapy. Oral mucositis affects an estimated 14% to 81% of patients undergoing some forms of chemotherapy, begins within days of initiating treatment, and lasts for up to 2 weeks depending on the dose, intensi...
Source: JAMA - Category: General Medicine Source Type: research
JACKSONVILLE, Fla. -- "Magic mouthwash," an oral rinse containing diphenhydramine, lidocaine and antacids, significantly reduced pain from oral mucositis, mouth sores, in patients receiving?radiation therapy for cancers of the head and neck when compared to placebo. These were the findings of a multi-institution, randomized, double-blind, placebo-controlled, phase III clinical trial, led by Robert Miller, M.D., [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
Conclusion: Minimizing mucositis-related impairments should be a main effort in oral cancer treatment to optimize patient outcome and improve quality of life after therapy.Oncol Res Treat
Source: Oncology Research and Treatment - Category: Cancer & Oncology Source Type: research
 Everyone has bad habits. Even your sainted Granny who seems perfect to you has some bad habit that only your grandfather knows about. Bad habits, like everything, exist on a spectrum, from biting your nails to snorting cocaine – and everything in between. In this episode, our hosts discuss bad habits that many people with mental illness seem to have – from smoking, to alcoholism, to drug use and, you guessed it, everything in between.   SUBSCRIBE &REVIEW “90% of people with schizophrenia smoke.” – Michelle Hammer   Highlights From ‘Bad Habits Mental Illness&rsq...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Addiction Habits Schizophrenia Stress Source Type: blogs
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