Bone tissue grown by applying vibration to stem cells in new study

New technology to grow 3D bone tissue in the lab by applying vibration to stem cells has been developed by Scottish researchers.A team from the University of the West of Scotland and the University of Glasgow created the revolutionary technique, which could make it possible to carry out bone grafting in a way that is less painful and risky for patients.How the new method works Presented at the Royal Society's Summer Science Exhibition, the method involves vibrating stem cells to a microscopic degree at high speeds, thus triggering them into becoming bone-producing cells. This approach, called nanokicking, would produce cells that could be implanted where needed, fusing with existing bone to heal damage or fractures.The vibrations required to cause this change in function are minuscule, shaking the cells by billionths of a metre. For this study, the researchers created a specialised device called a bioreactor to fulfil this specific purpose, which will soon be commercialised to make it available to other scientists and bone researchers.This makes it possible to grow 3D bone from multipotent stem cells - a type of cell that can grow into many types of tissue needed throughout the body, such as fat, cartilage and bone.The benefits Currently, bone is the second most commonly transplanted tissue in the world behind blood, but the process requires painful surgery to remove bone samples from other parts of the body, while also posing a risk of rejection of the new tissue.By cont...
Source: Arthritis Research UK - Category: Rheumatology Source Type: news

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Authors: Ge Y, Chen S, Luo Q, Wang CP, Hao J, He J, Chen X, Yang X, Li J, Chang YX Abstract Angelicae pubescentis radix (APR) is widely applied in treating rheumatoid arthritis in China. Coumarins are the major active compounds of APR extract including columbianetin, columbianetin acetate, osthole, and columbianadin. The in vivo behavior of the four major coumarins of APR has not been systematically reported. A feasible and reliable ultra-performance liquid chromatography (UPLC) method was established and validated for the quantification of the above four coumarins in rat various tissues (including heart, liver, sp...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
ConclusionThere was no significant association between the patterns of electronic devices use and CTS symptoms. The high prevalence of CTS symptoms necessitates awareness programs, especially among the young population. Although this work did not prove the association, further studies with confirmatory clinical testing are recommended.
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
Publication date: Available online 18 March 2019Source: Reumatología Clínica (English Edition)Author(s): Adriana Ivonne Céspedes Cruz, Myriam Méndez Núñez, Eunice Solís Vallejo, Maritza Zeferino Cruz, Alfonso Ragnar Torres Jiménez, Verónica Ocampo Sánchez, Beatriz Flores Meza, Norma Quintana RuizAbstractIntroductionJuvenile idiopathic arthritis (JIA) is a chronic autoimmune disease characterised by the presence of arthritis in children under 16 years of age for more than 6 weeks in the absence of any other known cause.The extra-articular manifestations, ...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
ConclusionBoth INSPIRE and Domjan methods correlate well as measures of SLF in PsA and correlate with radiographic damage. Therefore, the simpler INSPIRE method may be used to measure SLF in PsA.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Condition:   Active Psoriatic Arthritis Interventions:   Other: BMS-986165 Placebo;   Drug: BMS-986165 Dose A;   Drug: BMS-986165 Dose B;   Drug: Ustekinumab;   Other: Ustekinumab Placebo Sponsor:   Bristol-Myers Squibb Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: The primary goal of pharmacodynamic monitoring is to optimize the response, but it can also have an impact on safety, costs, patient adherence, etc. Ideally, the constant remote monitoring of patient-reported disease activity is expected to become the standard, facilitated by mHealth technologies.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Review Articles: Focus on Pharmacodynamic Drug Monitoring Source Type: research
CHICAGO—The Gout and Hyperuricemia scientific session at the 2018 ACR/ARHP Annual Meeting opened with a talk by Tony R. Merriman, PhD, a research professor at the University of Otago, New Zealand. His talk focused on molecular epidemiology, with an emphasis on the interactions between genes and environmental exposures, and their contributions to gout. Dr. Merriman... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Crystal Arthritis Meeting Reports 2018 ACR/ARHP Annual Meeting Gout Human Functional Genomics Projects hyperuricemia Source Type: research
CHICAGO—“You never know when things might happen,” began Kamala M. Nola PharmD, MS, vice chair and professor in the Department of Pharmacy Practice at Lipscomb College of Pharmacy, Nashville, at the 2018 ACR/ARHP Annual Meeting. Dr. Nola explained that on May 1, 2010, the Arthritis Foundation Arthritis Walk held on her university’s campus was moved... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Facility Meeting Reports Professional Topics 2018 ACR/ARHP Annual Meeting Disaster preparation Natural disaster Source Type: research
Krysta M. Felix, Fei Teng, Nicholas A. Bates, Heqing Ma, Ivan A. Jaimez, Kiah C. Sleiman, Nhan L. Tran, Hsin-Jung Joyce Wu
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: This study demonstrates that BP bark possesses anti-arthritic activity potential and confirm its folklore use in the treatment of inflammatory conditions.
Source: Indian Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
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