Could an obscure type of herpes virus trigger female infertility?
Conclusion Unexplained infertility causes distress for thousands of couples trying for a baby. It can be hard to accept that doctors can find no reason for a couple's inability to get pregnant, and many couples spend a lot of time and money trying fertility treatments. Finding a potential cause for unexplained infertility could raise a lot of people's hopes. This study has interesting results, but it was very small and needs to be replicated on a larger scale to be sure the results hold true. We also need to remember that this study cannot show causation – it can't tell us whether the virus is a cause of infertility, only that it seems to be more common in women with infertility not otherwise explained. Having said that, these women had unexplained infertility and there is still a lot that we don't know about them. The researchers say that they didn't have endometriosis, any problems with ovulation or any structural abnormalities of the reproductive system. However, we don't know any more than that, such as exploration of male factors for infertility, how long the woman/couple had been trying to conceive, prior miscarriages, or the success of future fertility treatment. We also know nothing about the control group – such as how they were recruited or why womb samples were taken – other than that they'd had a baby. They may have had problems conceiving themselves for all we know. Overall, it can't be said that the women with infertilit...
Crohn's disease and pregnancy can affect each other. However, most women who conceive while their Crohn's disease is in remission can have a normal pregnancy and healthy baby. Learn more here.
To protect a developing fetus from experimental drugs or treatments that might cause birth defects, pregnant women aren't included in many clinical trials. But that limits the safety evidence, too.(Image credit: Maria Fabrizio for NPR)
This article provides an overview of the symptoms, causes, and treatments for genital herpes.
Conditions: Chronic Lymphocytic Leukemia (CLL); Waldenstrom Macroglobulinemia (WM) Intervention: Drug: Shingrix vaccine Sponsor: University of Rochester Not yet recruiting
Conditions: Diabetes Mellitus; Pregnancy Complications Intervention: Drug: Faster-acting Aspart insulin Sponsor: Rigshospitalet, Denmark Not yet recruiting
Condition: Infertility, Female, Associated With Anovulation Interventions: Drug: clomiphene citrate; Procedure: Saline cervical flushing; Procedure: Intrauterine Autologous platelet-rich plasma Sponsor: Benha University Recruiting
Maternal use of medicines targeting neurotransmitter systems is unlikely to directly affect the risk of autism spectrum disorder in offspring, the authors of a study published in JAMA Psychiatry have concluded.
Publication date: Available online 10 December 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Md. Wasim Khan, Medha Priyadarshini, Jose Cordoba-Chacon, Thomas C. Becker, Brian T. LaydenAbstractHexokinase domain containing 1, a recently discovered putative fifth hexokinase, is hypothesized to play key roles in glucose metabolism. Specifically, during pregnancy in a recent genome wide association study (GWAS), a strong correlation between HKDC1 and 2-h plasma glucose in pregnant women from different ethnic backgrounds was shown. Our earlier work also reported diminished glucose toleran...
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