Fentanyl can cause serotonin syndrome

3.5 out of 5 stars Serotonin Syndrome Induced by Fentanyl in a Child: Case Report. Robles LA. Clin Neuropharmacol 2015 Sept-Oct;38:206-8. Abstract When many clinicians think of serotonin syndrome (SS), they consider the usual suspects: Selective Serotonin Uptake Inhibitors (SSRIs) Citalopram Fluoxetine Sertraline Escitalopram Paroxetine Serotonin-Norepinephrine Reuptake Inhibitors Venlafaxine Duloxetine Antidepressants Trazodone Buspirone Clomipramine Aside from these common culprits, there are other commonly used drugs whose clear association with serotonin syndrome is less-often realized: Fentanyl Methadone Tramadol Lithium Linezolid Ondansetron Metoclopramide Methylene blue Since many ICU patients are treated with fentanyl and/or antiemetics such as ondansetron, and have other conditions that can cause altered mental status, the diagnosis is frequently not suspected initially, and causative pharmaceutical agents not discontinued. This interesting report describes a 7-yead-old boy admitted to the intensive care unit after surgery for an intracerebral hemorrhage.Within 48 hours of admission, he developed the characteristic clinical triad of SS: altered mental status (consistent with his underlying condition,) inducible clonus and tremors, and autonomic instability (hyperthermia, hypertension, tachycardia.) Two days after surgery, clinicians considered the diagnosis of serotonin syndrome. They reviewed the patient’s medications and noted that fen...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical fentanyl opioid serotonin syndrome Source Type: news

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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar General Not Crazy Podcast Schizophrenia Source Type: blogs
Abstract One characteristic of ethylene glycol overdose is a cardiopulmonary syndrome including hypertension and pulmonary edema with pathology indicating damage to the endothelium of heart, lung and brain vessels. The mechanism of the cardiopulmonary toxicity is unknown, but has been linked with accumulation of the metabolite calcium oxalate monohydrate (COM) in the endothelium. These studies have evaluated the hypothesis that COM or the oxalate ion produces endothelial damage in vitro and that damage is linked with induction of reactive oxygen species (ROS). In cultured human umbilical vein endothelial cells (HU...
Source: Cardiovascular Toxicology - Category: Cardiology Authors: Tags: Cardiovasc Toxicol Source Type: research
Purpose of review Oxalate is a metabolic end-product promoting the formation of calcium oxalate crystals in urine. Massive urine oxalate excretion occurs in genetic diseases, mainly primary hyperoxaluria type I and II, threatening renal function. Ethylene glycol poisoning may induce the precipitation of calcium oxalate crystals in renal tubules, leading to acute renal failure. In both cases, oxalate results from glyoxylate transformation to oxalate in the liver, by lactate dehydrogenase (LDH) enzymes, especially the LDH-5 isoenzyme. The purpose of the review is to highlight LDH as a potential therapeutic target according...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: MINERAL METABOLISM: Edited by Aline Martin and Tamara Isakova Source Type: research
Conclusion The present study reported a low prevalence of myocardial injury requiring PCI in acute CO poisoning patients. Although myocardial injury due to coronary artery occlusion would be a very rare presentation in the setting of acute CO poisoning, coronary occlusion should be taken into consideration for elderly patients and/or patients who have coronary risk factors.
Source: European Journal of Emergency Medicine - Category: Emergency Medicine Tags: Original Articles Source Type: research
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CONCLUSIONS: The clinical presentation of a patient suffering from latrodectism places the clinician in front of a challenging differential diagnosis. Following the suspicion, the first-line doctor is invited to discuss the case with a toxicologist, in order to confirm or exclude the diagnosis and implement all therapeutic measures. In our clinical case, the absence of organic lesions, laboratory tests not suggestive for other causes, and the presence of typical clinical feature suggested the diagnosis of L tredecimguttatus poisoning. This hypothesis was then supported by the close temporal relation between antivenom admin...
Source: Toxicon - Category: Toxicology Authors: Tags: Toxicon Source Type: research
Conclusions: Comorbidities such as chronic hypertension and kidney failure were less frequent than in patients with other PRES etiologies. Imaging analysis did not highlight a specific pattern for poisoning-induced PRES. Although less described, PRES in the context of poisoning, which shares most of the clinical and radiological characteristics of other etiologies, is not to be ignored.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionsEnvironmental epidemiology has revealed that several organs and systems in the human body are targets of air pollutants. Current imaging methods that can assess the deleterious effects of pollutants includes a whole spectrum: radiography, US, CT and MRI. Future studies will help to reveal additional links among environmental disease networks.
Source: Insights into Imaging - Category: Radiology Source Type: research
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