Fentanyl can cause serotonin syndrome

3.5 out of 5 stars Serotonin Syndrome Induced by Fentanyl in a Child: Case Report. Robles LA. Clin Neuropharmacol 2015 Sept-Oct;38:206-8. Abstract When many clinicians think of serotonin syndrome (SS), they consider the usual suspects: Selective Serotonin Uptake Inhibitors (SSRIs) Citalopram Fluoxetine Sertraline Escitalopram Paroxetine Serotonin-Norepinephrine Reuptake Inhibitors Venlafaxine Duloxetine Antidepressants Trazodone Buspirone Clomipramine Aside from these common culprits, there are other commonly used drugs whose clear association with serotonin syndrome is less-often realized: Fentanyl Methadone Tramadol Lithium Linezolid Ondansetron Metoclopramide Methylene blue Since many ICU patients are treated with fentanyl and/or antiemetics such as ondansetron, and have other conditions that can cause altered mental status, the diagnosis is frequently not suspected initially, and causative pharmaceutical agents not discontinued. This interesting report describes a 7-yead-old boy admitted to the intensive care unit after surgery for an intracerebral hemorrhage.Within 48 hours of admission, he developed the characteristic clinical triad of SS: altered mental status (consistent with his underlying condition,) inducible clonus and tremors, and autonomic instability (hyperthermia, hypertension, tachycardia.) Two days after surgery, clinicians considered the diagnosis of serotonin syndrome. They reviewed the patient’s medications and noted that fentanyl wa...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical fentanyl opioid serotonin syndrome Source Type: news