Researchers Discover New Mesothelioma Blood Biomarker

An international team of scientists recently identified a new blood biomarker for mesothelioma that should help with early diagnosis, prognosis accuracy and the personalization of treatment. Researchers identified activin A, a protein complex found in the blood, as a potential target for future therapies. “Blood derived biomarkers are important because they can be noninvasively measured, even at multiple stages,” Dr. Balazs Hegedus, at the Medical University of Vienna in Austria, told Asbestos.com. “They can help make the best personalized therapeutic decisions.” In addition to Hegedus, cancer specialists from Hungary, Switzerland and Australia participated in the study published in the latest issue of European Journal of Cancer. They measured the activin A levels of 129 patients in four locations, 16 patients with nonmalignant pleural diseases and 45 healthy people for a comparison. Researchers found significantly higher activin A levels in patients with mesothelioma and increased tumor volume correlated directly with the higher levels of the circulating protein. They also discovered patients with lower levels of activin A at diagnosis lived significantly longer. Activin A Helps with Histology The patients with nonmalignant diseases had only a slight increase in activin A, which also helped determine the histological classification of mesothelioma. Those with sarcomatoid and biphasic mesothelioma — the two toughest types to treat — had sig...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: activin A asbestos cancer asbestos diseases Balazs Hegedus cancer treatment mesothelioma mesothelioma biomarker mesothelioma blood biomarker mesothelioma research multimodal cancer therapy treatments for mesothelioma Source Type: news

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Conclusion: The approaches of this review are to highlight the recent management advances and contrast the differences of treatment practice between Western and Asian countries.
Source: Current Cancer Therapy Reviews - Category: Cancer & Oncology Source Type: research
Scientists at the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital have uncovered a novel, two-agent immunotherapy combination that worked surprisingly well in animal models with malignant mesothelioma. The discovery has sparked new optimism for immunotherapy, which has struggled to provide consistently positive results with aggressive cancers such as mesothelioma. “This is the beginning of a new story of hope, a new combination of immunotherapy,” Dr. Mark Poznansky, director of the VIC and associate professor at Harvard Medical School, told Asbestos.com. “It worked quite well in a...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Dr. Antonio Giordano believes his team has cleared the path to the next breakthrough in the treatment of malignant pleural mesothelioma. The advancement involves a new use for an old drug, pyrvinium pamoate, which doctors have successfully used for more than 50 years to treat infections of pinworm parasite. “This drug that no one expected to be involved with mesothelioma is potentially a new weapon against this aggressive type of tumor,” Giordano told Asbestos.com. “Our findings are exciting, very exciting. This one can move forward.” Giordano is the founder and director of the Sbarro Health Researc...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Researchers at the Stanford University School of Medicine believe a patient-specific stem cell vaccine could become part of mesothelioma treatment — and possibly prevention — in the future. The belief stems from their recent study that demonstrated a consistent immunologic response with genetically-altered stem cells in laboratory mice carrying particular cancer cells. “This could potentially play a role for a large group of — if not all — cancers,” Dr. Joseph Wu, director of the Stanford Cardiovascular Institute, told Asbestos.com. “We envision it potentially being used as a vacci...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Cancer patients who opt for alternative therapy instead of conventional medicine significantly decrease their chances of survival, according to researchers at Yale School of Medicine. Although the popularity of alternative medicine continues to grow, a recent study published in the Journal of the National Cancer Institute found survival rates significantly reduced for those who use it as first-line therapy. Conventional cancer treatments — chemotherapy, surgery and radiation — still produce a much better chance of survival. Mesothelioma was not included in the study, but the findings are relevant to this rare ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: acupuncture cancer Alternative medicine alternative mesothelioma treatment alternative therapy survival alternative vs conventional medicine breast cancer colon cancer Conventional cancer treatments Dr. David Gorski Dr. Skyler Johnson Source Type: news
Dr. Tawee Tanvetyanon at the Moffitt Cancer Center in Tampa rarely sounds this enthused about the future prospects for patients with pleural mesothelioma. Finally, he has something promising to offer. Tanvetyanon is the principal investigator of a much-anticipated phase II clinical trial involving an immunotherapy drug combination with considerable potential for extending survival. “This is exciting. We now can offer something with realistic hope,” he told Asbestos.com. “We haven’t had anything like this for mesothelioma in a long time. I really look forward to speaking with these patients now.&rdqu...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Abramson Cancer Center Aduro Biotech CRS-207 Dr. Tawee Tanvetyanon FDA approval Keytruda improving mesothelioma prognosis Merck mesothelioma chemotherapy mesothelioma clinical trials mesothelioma immunotherapy moffitt cancer center m Source Type: news
A new experimental treatment combining a chemical found in red wine and a popular chemotherapy drug showed a powerful synergistic effect in targeting pleural mesothelioma cells. Researchers at Soon Chun Hyang University Hospital Cheonan in South Korea combined the platinum-based chemotherapy drug cisplatin with resveratrol, a natural antioxidant found in wine and red grapes. The result successfully induced apoptosis, or the process of natural cell death, in malignant mesothelioma cells. Cisplatin has long been one of the most popular drugs to treat mesothelioma and a variety of other cancers. But like many chemotherapy d...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: chemotherapy for mesothelioma cisplatin for mesothelioma mesothelioma treatment with red wine red wine for cancer resveratrol and cisplatin for cancer resveratrol in red wine Soon Chun Hyang University Hospital Cheonan Source Type: news
Malignant mesothelioma (MM) is a rare cancer type caused mainly by asbestos exposure. The median overall survival time of a mesothelioma cancer patient is less than 1‐year from diagnosis. Currently there are no curative treatment modalities for malignant mesothelioma, however treatments such as surgery, chemotherapy and radiotherapy can help to improve patient prognosis and increase life expectancy. Pemetrexed‐Cisplatin is the only standard of care (SoC) chemotherapy for malignant mesothelioma, but the median PFS/OS (progression‐free survival/overall survival) from the initiation of treatment is only up to 12 months....
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Cancer Therapy and Prevention Source Type: research
This study is part of a broad development program that includes a number of additional planned studies." TRACON Pharmaceuticals develops novel targeted cancer therapies. Its TRC105 antibody is directed at renal cell carcinoma and hepatocellular carcinoma. This clinical trial with TRC102 is one of five nationally involving methoxyamine, but one of more than 200 trials for mesothelioma.
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Research & Clinical Trials Source Type: news
The U.S. Food and Drug Administration (FDA) recently granted approval for immunotherapy drugs Keytruda and Opdivo to fight non-small cell lung cancer, raising the hopes of patients with malignant pleural mesothelioma. Drugmakers Merck &Co. and Bristol-Myers Squibb manufacture Keytruda (pembrolizumab) and Opdivo (nivolumab), respectively. Both drugs target PD-1 and PD-L1, specific proteins that block a body's immune system from attacking the cancer cells. Those same proteins were identified in a subset of mesothelioma patients with the shortest survival times. The University of Chicago Comprehensive Cancer Center re...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Treatment & Doctors Source Type: news
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