Virulence Potential of Staphylococcus Aureus Strains Isolated From Diabetic Foot Ulcers Among Patients From Southern Poland.

Virulence Potential of Staphylococcus Aureus Strains Isolated From Diabetic Foot Ulcers Among Patients From Southern Poland. Curr Vasc Pharmacol. 2016 Jun 24; Authors: Pobiega M, Myjak I, Pomorska-Wesolowska M, Romaniszyn D, Ziólkowski G, Chmielarczyk A, Maciag J, Szczyptaf A, Wójkowska-Mach J Abstract The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) was investigated among infected diabetic foot ulcers in hospitalized and non-hospitalized patients in southern Poland to assess the virulence patterns and antimicrobial resistance among these strains. MRSA was detected in 10.3% of all studied isolates, from the hospitalized patients only. The rest of the isolates was methicillin susceptible. The minimal inhibitory concentration that inhibits 50% of bacterial isolates (MIC50) for vancomycin was 1.0 mg/mL. The mupA gene was detected in six (8.8%) isolates, in one MRSA strain and five methicillin-sensitive S. aureus (MSSA) strains. Among the mupA-positive strains, two were resistant to mupirocin (1 MRSA and 1 MSSA). Such results raise serious concern about the usage of mupirocin in MRSA decolonization. The pvl gene was not detected among the study isolates. The majority of isolates (70.6%) possessed the lukE gene, with no significant difference in prevalence between MRSA and MSSA isolates. An interesting finding was the presence of enterotoxin genes among the study isolates. Diabetic foot may therefore be a reservoir of bacteri...
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research

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