Acanthamoeba Infection in a Drowning Child - Gunawan PI, Idarto A, Saharso D.

BACKGROUND: Acanthamoeba infection is a potential life-threatening complication of drowning. The management of drowning-associated Acanthamoeba infection remains controversial. Survival reports on Acanthamoeba infection have been on case reports only. CASE...
Source: SafetyLit - Category: Global & Universal Tags: Age: Infants and Children Source Type: news

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CONCLUSIONS: The scarcity of the studies trying to understand the compatibility as well as the exact mechanisms by which NDDS might be serving to enter the CNS infected by parasites opens new possibilities for further exploratory projects. There is an urgent need for new investments and motivations in the area of nanotechnology applied to the control of parasitic infectious diseases worldwide. PMID: 31612822 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Pathogenic protozoans use extracellular vesicles (EVs) for intercellular communication and host manipulation. Acanthamoeba castellanii is a free-living protozoan that may cause severe keratitis and fatal granulom...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
AbstractPurposeTo evaluate the in vitro efficacy of three commercial ophthalmic solutions (gatifloxacin, levofloxacin and gentamicin) against cysts ofAcanthamoeba species.DesignExperimental studyMethodsAcanthamoeba cysts belonging to genotypes T3, T4 and T5 were incubated with three ophthalmic solutions for different periods of time; 1, 24, 48 and 72  h at 37 °C. After incubation, treated cysts were stained with trypan blue and counted to express the percent of growth inhibition. Additionally, the viability of treated cysts was assessed by culturing them in PYG medium at 30 °C for 72 h as well a...
Source: International Ophthalmology - Category: Opthalmology Source Type: research
This patient with recurrent unilateral ocular complaints, a lid lesion, and keratitis unresponsive to numerous medications as well as a negative work-up for infectious agents leaves us with numerous diagnostic possibilities. These include: viral shedding from the lid lesion as with molluscum, eyelid deformity with corneal exposure, limbal stem cell deficiency of uncertain etiology, ocular surface dysplasia or neoplasia, superior limbic keratoconjunctivitis, vernal keratoconjunctivitis, herpes group viruses, Acanthamoeba keratitis, eyelid foreign body, medicamentosa, and many others.
Source: Journal of Cataract and Refractive Surgery - Category: Opthalmology Authors: Tags: Consultation section: Cataract Source Type: research
Eye, Published online: 25 September 2019; doi:10.1038/s41433-019-0589-6Acanthamoeba keratitis in Australia: demographics, associated factors, presentation and outcomes: a 15-year case review
Source: Eye - Category: Opthalmology Authors: Source Type: research
Eye, Published online: 25 September 2019; doi:10.1038/s41433-019-0597-6Repurposing drugs: Ca2+ ion dependency that can be exploited to treat keratitis caused by Acanthamoeba castellanii
Source: Eye - Category: Opthalmology Authors: Source Type: research
Authors: Bunsuwansakul C, Mahboob T, Hounkong K, Laohaprapanon S, Chitapornpan S, Jawjit S, Yasiri A, Barusrux S, Bunluepuech K, Sawangjaroen N, Salibay CC, Kaewjai C, Pereira ML, Nissapatorn V Abstract Acanthamoeba, one of free-living amoebae (FLA), remains a high risk of direct contact with this protozoan parasite which is ubiquitous in nature and man-made environment. This pathogenic FLA can cause sight-threatening amoebic keratitis (AK) and fatal granulomatous amoebic encephalitis (GAE) though these cases may not commonly be reported in our clinical settings. Acanthamoeba has been detected from different enviro...
Source: Korean Journal of Parasitology - Category: Parasitology Tags: Korean J Parasitol Source Type: research
To report the clinical and microbiological features of Acanthamoeba keratitis (AK) related to contact lens use in a tertiary hospital in China.
Source: BMC Ophthalmology - Category: Opthalmology Authors: Tags: Research article Source Type: research
Conclusions: In an in vitro assay, voriconazole reduced the cysticidal activity of 2 commonly used antiamoebic drugs. Although the in vivo drug interactions could be different, these observations may be useful in cases of nonhealing Acanthamoeba keratitis being treated with combination therapies that include voriconazole.
Source: Cornea - Category: Opthalmology Tags: Basic Investigation Source Type: research
Source: Acta Clinica Belgica - Category: General Medicine Authors: Source Type: research
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