Dexamethasone and High-Dose Methotrexate Improve Outcome for Children and Young Adults With High-Risk B-Acute Lymphoblastic Leukemia: A Report From Childrens Oncology Group Study AALL0232 [Pediatric Oncology]

Conclusion High-dose methotrexate is superior to Capizzi methotrexate for the treatment of high-risk B-acute lymphoblastic leukemia, with no increase in acute toxicity. Dexamethasone given during induction benefited younger children but provided no benefit and was associated with a higher risk of osteonecrosis among participants 10 years and older.
Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: Acute Lymphoblastic Leukemia Pediatric Oncology Source Type: research