Deals this week: Liquid Biotech, Entourage Phytolab, Mayne Pharma

Liquid Biotech USA has entered a research agreement with the University of Pennsylvania to study and utilise the circulating tumour cells (CTCs)-derived information to develop anti-cancer therapies through its precision medicine platform.
Source: Pharmaceutical Technology - Category: Pharmaceuticals Source Type: news

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Publication date: 1 November 2018Source: Materials Science and Engineering: C, Volume 92Author(s): Marjan Ghorbani, Hamed HamishehkarAbstractThe clinical applications of anticancer drugs are restricted due to the incomplete delivery to the cancerous tissue and the numerous drug resistance mechanisms involved in malignant cells. In this regard, stimuli-responsive nanomaterials offer a promising prospect to deal with these concerns. In the present study, ternary responsive hybrid gold/nanogels (Au/NGs) were synthesized as a new nanoplatform to simultaneously carry two anticancer drugs, i.e., doxorubicin (DOX) and 6-mercaptop...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In conclusion, our novel formulation destabilized H358 cells by using its acidic tumor microenvironment, thereby regulating cell apoptosis, proliferation, and metastatic properties.
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: 1 November 2018Source: Materials Science and Engineering: C, Volume 92Author(s): Yuanfang Huang, Ping Xie, Sheng-Tao Yang, Xuemei Zhang, Guangfu Zeng, Qian Xin, Xiao-Hai TangAbstractDrug delivery systems for doxorubicin (DOX) have attracted tremendous interest nowadays for the improved efficacy and/or reduced toxicity. Due to the aromatic structures and hydrophobic domains, carbon nanoparticle suspension injection (CNSI), a clinical applied reagent for lymph node mapping, strongly adsorbs DOX and holds great potential in cancer therapy. Herein, we evaluated the therapeutic effects of CNSI-DOX to establish...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In this study, novel molecularly imprinted polymer (MIP) microparticles containing methacryl polyhedral oligomeric silsesquioxane (M-POSS) were synthesized through the RAFT precipitation polymerization (RAFTPP) method using paclitaxel (PTX) as the templates. During the course of this investigation, methacrylic acid (MAA) was used as the functional monomer, while ethylene glycol dimethacrylate (EGDMA) was utilized as a cross-linker. The effects of different molar ratios of M-POSS on the microparticles were characterized. The obtained MIP microparticles were confirmed by FT-IR and TGA-DSC. The results of SEM showed regular s...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Chem. Commun., 2018, Advance Article DOI: 10.1039/C8CC03720E, CommunicationLei Xing, Jia-Liang Zhang, Tian-jiao Zhou, Yu-Jing He, Peng-Fei Cui, Jia-Hui Gong, Minjie Sun, Jin-Jian Lu, Zhangjian Huang, Liang Jin, Hu-Lin Jiang A polynuclear nanoparticle fabricated through a sequential hydrophobic and electrostatic interaction mechanism can circumvent the contradictory problem of siRNA binding capacity and toxicities of cationic vectors. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Publication date: Available online 19 July 2018Source: Cancer CellAuthor(s): Lingtao Jin, Jaemoo Chun, Chaoyun Pan, Dan Li, Ruiting Lin, Gina N. Alesi, Xu Wang, Hee-Bum Kang, Lina Song, Dongsheng Wang, Guojing Zhang, Jun Fan, Titus J. Boggon, Lu Zhou, Jeanne Kowalski, Cheng-Kui Qu, Conor E. Steuer, Georgia Z. Chen, Nabil F. Saba, Lawrence H. BoiseSummaryPlatinum-based chemotherapeutics represent a mainstay of cancer therapy, but resistance limits their curative potential. Through a kinome RNAi screen, we identified microtubule-associated serine/threonine kinase 1 (MAST1) as a main driver of cisplatin resistance in human ca...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Authors: Blagodatski A, Yatsunskaya M, Mikhailova V, Tiasto V, Kagansky A, Katanaev VL Abstract Medicinal mushrooms have been used throughout the history of mankind for treatment of various diseases including cancer. Nowadays they have been intensively studied in order to reveal the chemical nature and mechanisms of action of their biomedical capacity. Targeted treatment of cancer, non-harmful for healthy tissues, has become a desired goal in recent decades and compounds of fungal origin provide a vast reservoir of potential innovational drugs. Here, on example of four mushrooms common for use in Asian and Far East...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
ratti Micelles as colloidal suspension have attracted considerable attention due to their potential use for both cancer diagnosis and therapy. These structures have proven their ability to deliver poorly water-soluble anticancer drugs, improve drug stability, and have good penetration and site-specificity, leading to enhance therapeutic efficacy. Micelles are composed of hydrophobic and hydrophilic components assembled into nanosized spherical, ellipsoid, cylindrical, or unilamellar structures. For their simple formation, they are widely studied, either by using opposite polymers attachment consisting of two or more bl...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
The functionality of the tumor suppressor p53 is altered in more than 50% of human cancers, and many individuals with cancer exhibit amyloid-like buildups of aggregated p53. An understanding of what triggers the pathogenic amyloid conversion of p53 is required for the further development of cancer therapies. Here, perturbation of the p53 core domain (p53C) with subdenaturing concentrations of guanidine hydrochloride and high hydrostatic pressure revealed native-like molten globule (MG) states, a subset of which were highly prone to amyloidogenic aggregation. We found that MG conformers of p53C, probably representing popula...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Protein Structure and Folding Source Type: research
Cancer patients who receive complementary therapies are more likely to shun proven treatments, a study finds.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
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