AstraZeneca Sues FDA to Block Generic Crestor

With several ANDAs for generic versions of cholesterol treatment Crestor awaiting approval by the FDA, AstraZeneca is suing the agency to prevent approvals prior to May 2023.
Source: PharmaManufacturing.com - Category: Pharmaceuticals Source Type: news

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ConclusionsOur results suggest that metformin users are more likely to initiate preventive therapies and engage in other healthy behaviours. Failure to account for these behaviours may introduce healthy user bias into studies evaluating the effects of oral antihyperglycemic therapies.RésuméObjectifsLe biais lié aux utilisateurs sains selon lequel les patients ayant recours aux soins de santé sont plus susceptibles d'entreprendre des traitements préventifs et d'adopter des comportements sains liés au mode de vie est bien connu dans les études observationnelles, particuli&egra...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
ConclusionsSerum lipid levels are associated with depression per se, the depression severity, and the prospective 3-week course. These observations build the basis for future investigations on individualized lipid metabolism-related treatment strategies in depressed patients.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
In conclusion, the crude lipid extract of Artemisia integrifolia L could be used as a potential treatment to avert hyperlipidemia. Further studies to confirm these results in other models of hyperlipidemia (e.g., diet-induced obesity) are warranted.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Conclusion: This cross-sectional study found no associations between abnormal serum lipids or HOMA-IR and the presence of current asthma in children or adolescents. PMID: 30759963 [PubMed - as supplied by publisher]
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research
Conclusions: The presence of MetS, IR and dislipidemia rises with increasing SUAL independently of age, puberty, gender and body mass index (BMI) in OB/OW children. Patients with all of the MetS criteria had the highest SUAL. These results demonstrated that association between UA and metabolic and cardiovascular risk factors could be detectable as early as in childhood. Thus, we recommend monitoring SUAL in OB children and we believe that prevention of SUAL elevation in early life has a potential protective effect on metabolic impairment and subsequent comorbidities. PMID: 30759960 [PubMed - as supplied by publisher]
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research
This study compared exercise videogames with standard exercise modalities for improving uptake and maintenance of moderate to vigorous physical activity, and health risk indices.Study designA three-arm clinical RCT including 12 weeks of supervised laboratory-based moderate to vigorous physical activity followed by 6 months follow-up.Setting/participantsThis study was conducted at a university affiliated hospital research lab. Healthy, sedentary adults were eligible.InterventionsThis study compared a 12-week program of supervised exercise videogames versus standard exercise (e.g., treadmill) versus control. Data were collec...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
BEST SUPPLEMENTS: The leading cause of heart attacks is coronary heart disease, which is caused by having too much cholesterol in the blood. Keep cholesterol levels low and keep the heart healthy with three essential supplements.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS In this study, various biochemical markers were evaluated for possible association with left ventricle MPI as a surrogate of cardiac performance. Among these biomarkers, only low-density lipoprotein was significantly associated with MPI in elite athletes. PMID: 30760696 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
This Monday evening our next podcast becomes available. Dr. Gustavo Heudebert and I discuss another article about risk prediction. This topic has become a recurring theme on the Annals On Call podcast. Why is risk prediction so important? In 2019 we make many decisions about prevention and testing based on risk prediction. In addition we also estimate harms and benefits. All these predictive models have advantages and flaws. In making a decision for statin use (another upcoming episode), we have to estimate the risk of cardiovascular events, how much taking a statin will decrease that risk, and the probability and type...
Source: DB's Medical Rants - Category: Internal Medicine Authors: Tags: Medical Rants Source Type: blogs
Publication date: Available online 15 February 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Menno Hoekstra, Joya E. Nahon, Laura M. de Jong, Mara J. Kröner, Lidewij R. de Leeuw, Miranda Van EckAbstractThe nuclear receptor liver X receptor (LXR) impacts on cholesterol metabolism as well as hepatic lipogenesis via transcriptional regulation. It is proposed that inhibition of the protein arginine methyltransferase 3 (PRMT3) uncouples these two transcriptional pathways in vivo by acting as a specific lipogenic coactivator of LXR. Here we validated the hypothesis that treatment wit...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
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