When Parents Get Cancer, Children Are Often The Forgotten Victims

On the first day of spring 2007, Francesca Giessmann, 43, a marketing executive and holistic health coach from Kirkland, Washington, was rushed to the emergency room with severe stomach pain. After running numerous tests, doctors gave her the diagnosis of stage 3 non-Hodgkin lymphoma. Shocked and saddened by the news of her cancer, Giessmann's thoughts quickly turned to her son, Leo, who'd turned 3 years old the month prior. "Leo was very young and could not fully understand what was going on," Giessmann said. "Our pediatrician suggested we try to keep everything normal. I spent a great deal of time in bed. Leo related to my disease based on my port. He thought I had a boo-boo." Giessmann, who has had an enormous amount of health complications and side effects since her cancer treatment, said that when Leo turned 6 years old, he told her he was afraid his parents were going to die and he would be left alone. Leo is now, as Geissmann describes him, an articulate preteen who's come to terms with his mom's cancer. "I've often heard him say how his mom had cancer and 'she beat it,'" Giessmann said. "It is equal parts heartbreaking and heartwarming. He is very protective of me. My cancer has made him grow up a bit too fast. He's more sensitive and I think he has an understanding of the fragility of life." Millions with cancer Cancer affects the entire family. But the emotional and psychosocial impact on a child whose parent has canc...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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In conclusion, we conclude that piRNAs are abundant in human stomachs and may play important roles in the etiological processes of gastric cancers. PMID: 30896887 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Shi R, Wang C, Fu N, Liu L, Zhu D, Wei Z, Zhang H, Xing J, Wang Y Abstract Multiple drug resistance (MDR) and metastasis have been identified as the two major causes of the poor prognosis of patients with breast cancer. However, the relationship between MDR and metastasis has not been characterized. Epithelial‑mesenchymal transition (EMT), a process known to promote metastasis in cancer, has been shown to be associated with the MDR phenotype of many tumor types. Reduced cytokeratin 18 (CK18) expression is thought to be one of the hallmarks of EMT, and the role of CK18 in MDR of metastatic breast cancer r...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
In conclusion, apoptin‑induced cell death may involve both autophagy and apoptosis. The induction of autophagy may inhibit apoptosis, whereas apoptosis may inhibit autophagy; however, occasionally both pathways operate at the same time and involve apoptin. This apoptin‑associated selection between tumor cell survival and death may provide a potential therapeutic strategy for breast cancer. PMID: 30896879 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: He F, Fang L, Yin Q Abstract PDZ domain containing 2 (PDZD2) is a multi-PDZ domain protein that promotes the proliferation of insulinoma cells, and is upregulated during prostate tumorigenesis. However, the function of PDZD2 in other cancers, including osteosarcoma (OS), remains unclear. Dysregulation of microRNAs (miRNAs) contributes to tumor initiation, proliferation and metastasis, via the regulation of their target genes. The present study investigated the functions of miR-363 and PDZD2 in MG-63 OS cells. The results revealed that MG-63 cells contained low levels of miR-363, and that overexpression of ...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Cheng Z, Shao X, Xu M, Wang J, Kuai X, Zhang L, Wu J, Zhou C, Mao J Abstract Colorectal carcinoma (CRC) is one of the most common malignancies worldwide and the second leading cause of cancer‑related deaths in the US. Recently, Rab1A has been reported to be an activator of mTORC1 and p‑S6K1, which is downstream of mTORC1. However, the association between Rab1A and p‑S6K1 in CRC remains elusive. In the present study, we first demonstrated that Rab1A was overexpressed in CRC tissues and Rab1A overexpression was positively related to lymph node invasion, degree of differentiation, venous invasion and tu...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
In conclusion, the combination of isothiourea derivatives and hyperbaric oxygenation appears to be a promising therapeutic approach for malignant glioma treatment. PMID: 30896865 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Guo C, Liang C, Yang J, Hu H, Fan B, Liu X Abstract As a core kinase in the Hippo pathway, large tumor suppressor kinase 2 (LATS2) regulates cell proliferation, migration and invasion through numerous signaling pathways. However, its functions on cell proliferation, migration and invasion in glioma have yet to be elucidated. The present study revealed that LATS2 was downregulated in glioma tissues and cells, as determined by reverse transcription‑quantitative polymerase chain reaction and immunohistochemistry. In addition, Cell Counting Kit‑8, scratch wound healing and Transwell assays revealed that ov...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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