Novel Drug Shows Promise in T-Cell Lymphoma

DENVER (MedPage Today) -- An investigational drug, resiquimod, successfully healed cutaneous T-cell lymphoma lesions in a small peer-supported trial, researchers reported here.
Source: MedPage Today Dermatology - Category: Dermatology Source Type: news

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Publication date: Available online 15 February 2019Source: Radiation Physics and ChemistryAuthor(s): S.B. Almeida, D. Villani, R.K. Sakuraba, A.C.P. Rezende, L.L. CamposAbstractThe Total Skin Electron Beam (TSEB) therapy is a technique that aims to provide skin surface homogeneous absorbed dose in order to treat cutaneous T-cell lymphomas, both for curative and palliative purposes with electron beams penetrating a few millimeters into the skin, reaching the affected parts without affecting internal organs. In vivo dosimetry has become an important role for the treatment of total skin irradiation within a rigorous quality a...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
ConclusionThe reason for the association between the high serum copper levels and adverse prognosis is unknown. We hypothesized that interleukin-6 is secreted primarily by non-neoplastic cells at MF skin sites, leading to release of copper by the liver. Local production of interleukin-6 at the lesion sites might conceivably also promote neoplastic cell progression by stimulation of the STAT3 pathway. Further studies on the relationship between activated tumor-associated macrophages, serum copper levels, interleukin-6, or C-reactive protein and prognosis might be informative.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
A 34-year-old Japanese woman presented with widespread scaly erythema that had enlarged over 2 years. A skin biopsy revealed the diagnosis of mycosis fungoides (patch stage, T1b N0 M0 B0), a most frequent cutaneous T-cell lymphoma. 18F-FDG PET/CT scan unexpectedly showed intense uptake on the left sole, which suggested a tumorous mycosis fungoides lesion (SUVmax = 6.2). Careful examination revealed the mass to be a typical plantar wart of 2 cm in diameter that the patient had not recognized. With repeated cryotherapy, the wart disappeared in 6 months, and follow-up 18F-FDG PET/CT showed no abnormal uptake on the left sole.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
CONCLUSIONS: This work offers insight into the heterogeneity of SS, providing better understanding of the transcriptomic diversities within a clonal tumor. This transcriptional heterogeneity can predict tumor stage and thereby offer guidance for therapy. PMID: 30718356 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
Abstract BACKGROUND:: Intractable pruritus affects an estimated 83% of patients with advanced cutaneous T-cell lymphoma. Palliative care strategies to improve outcomes for these patients are lacking. Lignocaine antagonises kappa opioid antagonist-induced scratching in mice models and may relieve cutaneous T-cell lymphoma-pruritus. PRACTICE CHALLENGE:: The aim of this retrospective case series was to evaluate our clinical experience with low-dose continuous subcutaneous infusion lignocaine for intractable pruritus associated with cutaneous T-cell lymphoma, from 2000 to 2015. The study received approval from Re...
Source: Palliative Medicine - Category: Palliative Care Authors: Tags: Palliat Med Source Type: research
In this study we analyzed immortalized patient-derived cells and primary CTCL patient samples using RT-PCR, western blotting and confocal microscopy and found that proteins critically involved in meiosis and LINE-1 retrotransposition are expressed and are associated with chromosomal instability and DNA DSB formation. Using cell cycle synchronization, we show G1/S phase-transition-specific expression of meiosis proteins. Using the Alu retrotransposition assay, we demonstrate the functional activity of LINE-1 retrotransposon in CTCL. Histone acetyltransferase inhibition results in downregulation of the ectopic germ cell prog...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Publication date: Available online 31 January 2019Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): P. Martín-Carrasco, M. Morillo-Andújar, M. Sendín-Martín, J. Conejo-Mir
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
Follicular mucinosis in association with systemic hematologic disorders other than mycosis fungoides is poorly characterized. Clinicopathological features of follicular mucinosis in the setting of hematopoietic stem cell transplantation and diverse systemic hematologic malignancies differ from mycosis fungoides-associated cases and follicular mucinosis is not necessarily a precursor to cutaneous T-cell lymphoma.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
Mycosis Fungoides (MF) and S ézary Syndrome (SS) are the most common types of primary cutaneous T cell lymphomas. The clinical presentation of MF is generally indolent whereas SS represents a more aggressive variant. Stage at diagnosis is the most important determinant of long-term survival outcome. Although most patients pres ent with early stage, patients who develop progressive disease or have advance stage represent a therapeutic challenge owing to the lack of effective therapies. Allogeneic HCT has been used as a potentially curative treatment modality because autologous HCT, conventional chemotherapies and new...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 599 Source Type: research
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