Continued Role of Splenectomy in the Management of Patients With Myelofibrosis
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by bone marrow fibrosis, cytopenias, extramedullary hematopoiesis, systemic symptoms, splenomegaly, and evolution to acute myeloid leukemia. Patients with polycythemia vera (PV) and those with essential thrombocythemia (ET) can progress to MF (post-PV or post-ET MF). Complications related to splenomegaly include mechanical symptoms (pain, early satiety, diarrhea, and bloating), manifestations of portal hypertension, and cellular sequestration resulting in exacerbation of existing cytopenias.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Daniel Aruch, Myron Schwartz, John Mascarenhas, Marina Kremyanskaya, Carrie Newsom, Ronald Hoffman Tags: Case Report Source Type: research
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