Alpha2delta ligands, gabapentin, pregabalin and mirogabalin: a review of their clinical pharmacology and therapeutic use.

Alpha2delta ligands, gabapentin, pregabalin and mirogabalin: a review of their clinical pharmacology and therapeutic use.
Expert Rev Neurother. 2016 Jun 27;
Authors: Calandre EP, Rico-Villademoros F, Slim M
Abstract
INTRODUCTION: The first two alpha2delta ligands -gabapentin and pregabalin- were initially synthesized as antiepileptics; however, they were later also found to be useful for the treatment of additional conditions.
AREAS COVERED: Relevant publications describing potential underlying mechanisms, clinical pharmacokinetics/pharmacokinetics, and clinical efficacy and safety of these drugs in various disease conditions were searched in PubMed and Scopus and included in this review. Expert commentary: Gabapentin and pregabalin are effective for the treatment neuropathic pain, fibromyalgia and epilepsy; in addition, they may be useful for the reduction of postoperative pain. Pregabalin is also effective for the treatment of generalized anxiety disorder and gabapentin for the treatment of restless legs syndrome. Gabapentin may be considered a treatment option for pain associated with Guillain-Barré Syndrome and phantom limb and for the management of uremic pruritus. Mirogabalin, recently developed, is being investigated for the treatment of peripheral neuropathic pain and fibromyalgia, showing promising results in patients with diabetic peripheral neuropathy. Their most frequent adverse reactions are of neuropsychiatric ...

Source: Expert Review of Neurotherapeutics - June 28, 2016 Category: Neurology Tags: Expert Rev Neurother Source Type: research