Effects of ospemifene, a novel selective estrogen-receptor modulator, on human breast tissue ex vivo

Objective: Ospemifene (Osp) is a novel selective estrogen-receptor modulator (SERM) accepted for the treatment of dyspareunia, a symptom of postmenopausal vulvovaginal atrophy. We aimed to analyze the effects of Osp on human breast tissue (HBT), in comparison with the clinically established SERMs raloxifene (Ral) and tamoxifen (Tam), using ex vivo explant cultures. Methods: HBT samples were obtained from postmenopausal women undergoing mammoplasty and cultured with or without Osp, Ral, Tam, or 17β-estradiol (E2) for 7 and 14 days, and studied for morphology, proliferation, and apoptosis. The expression of epithelial markers, the estrogen-receptor alpha (ERα), the androgen receptor (AR), TFF1, and apolipoprotein D was evaluated using immunohistochemistry and quantitative reverse transcription-polymerase chain reaction. The PvuII polymorphism of ERS1 was determined. Results: Osp, similar to Ral and Tam, decreased the number of proliferating cells in a concentration-dependent manner (at 100 nM, P 
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research

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Authors: Başer E, Seçkin KD, Kadiroğullari P, Kiyak H Abstract BACKGROUND/AIM: To investigate the risk of de novo stress urinary incontinence (SUI) occurrence in women who were treated for pelvic organ prolapse (POP) with sacrospinous ligament fixation (SSLF) in addition to vaginal hysterectomy (VAH) and antero-posterior colporrhaphy (CAP) over a 24 month follow up period. MATERIALS AND METHODS: A prospective randomized study was designed. Women without occult or obvious SUI were randomized into either one of the study groups: Group1: VAH+CAP, and Group2: VAH+CAP+SSLF. Postoperatively, the patients wer...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
A new study'suggests that select [per- and polyfluoroalkyl substances] PFAS serum concentrations are associated with earlier natural menopause, a risk factor for adverse health outcomes in later life. 'Medscape Medical News
Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news
THURSDAY, June 4, 2020 -- Perfluoroalkyl substances (PFAS) are associated with earlier natural menopause, according to a study published online June 3 in the Journal of Clinical Endocrinology&Metabolism. Ning Ding, from the University of...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
According to a study published in theJournal of Clinical Endocrinology& Metabolism, exposure to PFAS chemicals found in water proof and non-stick products may speed up the onset of menopause  in women. Medical Xpress
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
According to a study published in theInternational Journal of Cancer, light pollution at night time may increase breast cancer risk by 10% in post-menopausal women.inews
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
The functional characterization and regulation of tissue resident and non-resident CD8+ T cells in the human female reproductive tract (FRT) as women age remains a gap in our knowledge. Here we characterized the cytotoxic activity and granular contents of CD8+ T cells from the FRT in pre- and postmenopausal women. We found that under steady-state conditions, CD8+ T cells from endometrium (EM), endocervix and ectocervix displayed direct cytotoxic activity, and that cytotoxicity increased in the EM after menopause. Cytotoxic activity was sensitive to suppression by TGFβ exclusively in the EM, and sensitivity to TGF&beta...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
SPONSORED POST By BAYER G4A Digital health is changing the world From chronic disease management to prevention, G4A’s goal is to empower people with the tools and access they need to take control of their health. G4A does this through fostering a diverse and vibrant ecosystem of digital health partners to support their growth and impact. On April 20th, G4A launched its 2020 Partnership Program with an open call for applications. The aim of the Partnerships Program is to work with companies across the globe on healthcare’s toughest challenges and innovate together towards a future of integrated ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health Tech Bayer Bayer G4A Bayer G4A Partnerships Program digital health Source Type: blogs
Source: International Journal of Womens Health - Category: OBGYN Tags: International Journal of Women's Health Source Type: research
AbstractPrevious studies reported heterogeneous associations between obesity and reproductive-related breast cancer risk factors and breast cancer intrinsic subtypes; however, few studies have been conducted in Asian populations. Here, we aimed to examine whether risks associated with established breast cancer risk factors varied by breast cancer subtypes in Chinese women. We conducted a hospital-based case-control study in Hong Kong, including a total of 2169 Chinese women. Unconditional polytomous logistic regression models were used to calculate adjusted odds ratios (AORs) and 95% confidence intervals(95%CIs) to estimat...
Source: Hormones and Cancer - Category: Cancer & Oncology Source Type: research
Daily dairy intake does not bolster bone mineral density at the femoral neck or lumbar spine, nor does it reduce osteoporotic fracture risk in women going through menopause.Medscape Medical News
Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news
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