AstraZeneca Pushes to Protect Crestor From Generic Competition

The drug maker is trying to get its popular anticholesterol pill approved to treat children who have a rare disease characterized by high cholesterol.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Crestor (Drug) Law and Legislation Cholesterol AstraZeneca PLC Drugs (Pharmaceuticals) Children and Childhood Generic Brands and Products Food and Drug Administration Source Type: news

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We describe phenomena using science, which gives us a sense of understanding and structure – yet we often lack actual understanding about what we’re observing, or why our treatments work. We have scientific explanations that may appear solid at first glance, but are flimsy upon closer inspection. More commonly, I imagine, we rely on scientific explanations as heuristics to enable us to get through our days, as a scaffold upon which to organize our information. I suspect AI is viscerally uncomfortable, and challenging to apply to clinical care or drug discovery (see part 2), because of the psychological importan...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Artificial Intelligence Pharmaceuticals Physicians AI David Shaywitz Health Tech Source Type: blogs
In this report, we propose that the molecular mechanisms of beneficial actions of CR should be classified and discussed according to whether they operate under rich or insufficient energy resource conditions. Future studies of the molecular mechanisms of the beneficial actions of CR should also consider the extent to which the signals/factors involved contribute to the anti-oxidative, anti-inflammatory, anti-tumor and other CR actions in each tissue or organ, and thereby lead to anti-aging and prolongevity. RNA Interference of ATP Synthase Subunits Slows Aging in Nematodes https://www.fightaging.org/archives/...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The elucidation of the molecular basis of the rare disease, sitosterolemia, has revolutionized our mechanistic understanding of how dietary sterols are excreted and how cholesterol is eliminated from the body. Two proteins, ABCG5 and ABCG8, encoded by the sitosterolemia locus, work as obligate dimers to pump sterols out of hepatocytes and enterocytes. ABCG5/ABCG8 are key in regulating whole-body sterol trafficking, by eliminating sterols via the biliary tree as well as the intestinal tract. Importantly, these transporters keep xenosterols from accumulating in the body. The sitosterolemia locus has been genetically associat...
Source: The Journal of Lipid Research - Category: Lipidology Authors: Tags: Thematic Reviews Source Type: research
Homozygous familial hypercholesterolaemia (HoFH) is characterized by a markedly increased risk of premature cardiovascular (CV) events and cardiac death. Lomitapide reduces low-density lipoprotein cholesterol ...
Source: Orphanet Journal of Rare Diseases - Category: Internal Medicine Authors: Tags: Research Source Type: research
(University of Pennsylvania School of Medicine) Decreased HDL and ApoA-l levels in the general population are associated with an increased risk of death from cardiomyopathy and heart failure. Researchers found the FA patients had serum ApoA-I levels lower than healthy control subjects. In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol-lowering drug increased a precursor of HDL (high-density lipoprotein), the " good cholesterol. "
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
See something of interest? Please share our postings with colleagues in your institutions! Spotlight Last chance to register! NNLM is offering stipends of up to $500 to support public library staff’s travel and lodging for the Health Information for Public Librarians Symposium at the MLA Annual meeting in Atlanta, GA. First come, first serve! Learn more about eligibility and instructions on how to apply. NNLM MAR will also purchase roundtrip airfare for public library staff from our region (Delaware, New Jersey, New York, and Pennsylvania). Please Note: If your application is accepted, NNLM MAR staff will be in touch...
Source: NN/LM Middle Atlantic Region Blog - Category: Databases & Libraries Authors: Tags: Weekly Postings Source Type: news
Annually, more than 20,000 hematopoietic cell transplantation (HCTs) are performed in the United States for malignant as well as nonmalignant (often rare) diseases of childhood [1]. Long-term survivors of HCT are at an increased risk of death from long-term sequelae as well as increased risk of cardiovascular disease [2]. Current international guidelines recommend frequent monitoring of long-term survivors for the development of metabolic syndrome (MetS) [3,4] —a constellation of central obesity, high blood pressure, low high-density lipoprotein (HDL) cholesterol, elevated fasting blood glucose, and triglycerides&mda...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Lysosomal acid lipase deficiency is an autosomal recessive metabolic disease with a wide range of severity from Wolman Disease to Cholesterol Ester Storage Disease. Recently enzyme replacement therapy with seb...
Source: Orphanet Journal of Rare Diseases - Category: Internal Medicine Authors: Tags: Research Source Type: research
TMEM199 deficiency was recently shown in four patients to cause liver disease with steatosis, elevated serum transaminases, cholesterol and alkaline phosphatase and abnormal protein glycosylation. There is no inf...
Source: Orphanet Journal of Rare Diseases - Category: Internal Medicine Authors: Tags: Research Source Type: research
Autosomal recessive hypercholesterolemia (ARH) is a very rare disease, caused by mutations in LDL protein receptor adaptor 1 (LDLRAP1). It is characterized by high levels of low-density lipoprotein cholesterol (LDL-C) and increased risk of premature cardiovascular disease. We aimed to characterize ARH in Spain.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
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