Zimmer Biomet clears U.S. anti-trust waiting period on LDR Holding acquisition

Zimmer Biomet (NYSE:ZBH) said today that its pending, $1 billion acquisition of LDR Holding (NSDQ:LDRH) cleared the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act. The $37-per-share offer for LDR, which makes the Mobi-C cervical disc replacement and Mivo lumbar and cervical fusion devices, is slated to expire at midnight July 13; today Zimmer said it expects to close the deal during the 3rd quarter. Zimmer Biomet has said it doesn’t expect the deal to affect its sales outlook, with adjusted earnings per share likewise unaffected until accretion kicks in after 2017; the company said it plans to issue updated guidance once the acquisition closes. At that point LDR would be folded into Zimmer Biomet’s spine &CMF business, led by president Adam Johnson. LDR CEO Cristophe Lavigne and LDR co-founder and GM Patrick Richard will remain with the company in “key leadership positions” within the spine biz, Warsaw, Ind.-based ZBH said when the LDR deal was announced. Zimmer Biomet said it’s financing the buyout with cash and a revolving credit facility; a senior notes offering worth $750 million is also in the offing. In March, Zimmer Biomet said it closed its buyout of Cayenne Medical and its soft tissue reconstruction devices for an unspecified amount. Scottsdale, Ariz.-based Cayenne makes devices for knee and shoulder repair, including the AperFix II, CrossFix II and iF...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Mergers & Acquisitions Orthopedics Wall Street Beat LDR Holding Corp. Zimmer Biomet Source Type: news

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A young and thin female patient entered the preoperative area accompanied by an older male for repair of an open fracture of her arm. The perianesthesia nurse observed that the patient failed to make any eye contact and had healing bruises on her arms ...
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Abstract The development of colorectal cancer (CRC) is a multistep process initiated by a benign polyp that has the potential to evolve into in situ carcinoma through the interactions between environmental and genetic factors. CRC incidence rates are constantly increased for young adult patients presenting an advanced tumor stage. The majority of CRCs arise from colonic adenomas originating from aberrant cell proliferation of colon epithelium. Endoscopic polypectomy represents a tool for early detection and removal of polyps, although the occurrence of cancers after negative colonoscopy shows a significant inciden...
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In this study, we have investigated the role of all-trans-retinoic acid (RA) as a neuroprotective agent against Aβ 1-42-induced DNA double-strand breaks (DSBs) in neuronal SH-SY5Y and astrocytic DI TNC1 cell lines and in murine brain tissues, by single-cell gel electrophoresis. We showed that RA does not only repair Aβ 1-42-induced DSBs, as already known, but also prevents their occurrence. This effect is independent of that of other antioxidants studied, such as vitamin C, and appears to be mediated, at least in part, by changes in expression, not of the RARα, but of the PPARβ/δ and of antiamylo...
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