Ask JJ: Osteoarthritis

Dear JJ: I'm a 67-year-old woman who recently got diagnosed with osteoarthritis. My doctor warned me as an older woman, I'm more susceptible to this problem along with fractures and other problems it presents. I don't want to go on prescription drugs, and I know you're big on natural remedies. Can you help me out here? Osteoarthritis (OA) is a degenerative joint disease, the most common form of arthritis, and sometimes called the "wear and tear" arthritis. A little background: Bones intersect to form a joint. Those bones need a buffer to prevent painful friction. Cartilage--a tough, flexible connective tissue that protects your bones from rubbing together--becomes that buffer. OA occurs when cartilage wears down, exposing bone to bone and resulting in joint pain, stiffness, tenderness, inflammation, and other issues that range from mild discomfort to debilitating suffering. Your body has an amazing ability to repair and recover. If you've ever pulled a muscle or broken a bone, you know the process your body goes through to heal. Unfortunately, unlike other tissue, cartilage doesn't get a steady supply of blood vessel. That's one reason it diminishes with age and doesn't regenerate as quickly. As you've learned, women, particularly postmenopausal women, become more vulnerable to OA than men. In fact, studies show OA (along with osteoporosis) affects about 60 percent of postmenopausal women. You can't change your gender, genes, or age, but building healthy c...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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Conclusions: The constantly increasing prevalence of NAFLD in the general population can contribute to a growing role of NAFLD/NASH in HCC epidemiology. Moreover, some particular challenges specific for patients with liver steatosis may impede proper HCC diagnosis, treatment and follow-up. PMID: 31631714 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
CONCLUSIONS: Perioperative, i.v. lidocaine administration influences postoperative serum concentrations of endocannabinoids and NAEs in children. PMID: 31630508 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Abstract The purpose of this study was to explore interactions between limited English proficiency (LEP) status, as a function of risk status (low math performance at the start of the school year), on computation and word-problem solving performance. Among 260 1st-grade students, classified as at-risk (AR) or not at-risk (NAR) for math disability, we compared the performance of LEP students to native English-speaking peers. A series of 2-way ANOVAs were conducted on computation and word-problem solving skill at 2 time points, fall and spring of 1st-grade. On fall computation measures, there was no main effect for ...
Source: Learning Disability Quarterly - Category: Disability Authors: Tags: Learn Disabil Q Source Type: research
CONCLUSIONS: The use of both prescription drugs and supplements increased over time, except for decreases in ginkgo and vitamin E. Prescription drug use appeared in line with prescribing guidelines. Supplement use was associated with higher education and better self-rated health; it persists despite a lack of supportive evidence. PMID: 31633558 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
CLINICS IN PERINATOLOGY
Source: Clinics in Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research
Conclusion: The presentation of PPCRA has been sporadic in the majority of cases. Inflammatory and hereditary origins have been anecdotally cited. Our young patient showed concurrent presentation of inflammatory and hereditary origin of PPCRA. We suggest that a careful investigation of systemic inflammation should be done in children with suggestive extraocular symptoms in the setting of PPCRA. PMID: 31631731 [PubMed - as supplied by publisher]
Source: Ophthalmic Genetics - Category: Opthalmology Tags: Ophthalmic Genet Source Type: research
This study aims to verify if clinical parameters, such as waist circumference and/or body mass index and biohumoral and inflammatory parameters can help predict cardiac structural and functional alterations, through an echocardiogram test in obese children and adolescents. Children were prospectively enrolled at the AUOC outpatients' department of Emergency Paediatrics, University Hospital, Messina, from June to December 2017. Clinical, metabolic parameters and an inflammation marker (HMGB1) were evaluated and a transthoracic echocardiogram was carried out. Twenty-two obese subjects were prospectively enrolled.HMGB1 values...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Bone is richly innervated by nerve growth factor–responsive (NGF-responsive) tropomyosin receptor kinase A–expressing (TrKa-expressing) sensory nerve fibers, which are required for osteochondral progenitor expansion during mammalian skeletal development. Aside from pain sensation, little is known regarding the role of sensory innervation in bone repair. Here, we characterized the reinnervation of tissue following experimental ulnar stress fracture and assessed the impact of loss of TrkA signaling in this process. Sequential histological data obtained in reporter mice subjected to fracture demonstrated a marked ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
NEW YORK (Reuters Health)—Iguratimod, a disease-modifying drug marketed in China and Japan, appears to be effective in treating rheumatoid arthritis (RA) and possibly other autoimmune diseases, while protecting against adverse bone effects, researchers from China say. Iguratimod is a methane sulfonanilide compound that influences several anti-inflammatory and immune-modulatory pathways and has an anabolic effect on... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: DMARDs & Immunosuppressives Drug Updates Autoimmune disease bone China iguratimod Source Type: research
Moxibustion alleviates intervertebral disc degeneration via activation of the HIF-1α/VEGF pathway in a rat model. Am J Transl Res. 2019;11(9):6221-6231 Authors: Zhang B, Zhao Q, Li Y, Zhang J Abstract Intervertebral disc degeneration (IDD) induces serious back, neck and radicular pain. Recently, moxibustion has been suggested as an effective treatment for IDD. Thus, our study aims to investigate the molecular mechanism of moxibustion in IDD. A rat model of IDD was established by moxibustion treatment. Nucleus pulposus (NP) cells isolated from IDD rats or IDD rats treated with moxibustion were tra...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
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