Hormone replacement therapy and the risk of endometrial cancer: A systematic review

The median age at menopause in Europe and North America ranges from 50.1 to 52.8 years [1]. Menopausal symptoms comprise vasomotor symptoms, declining bone mass, vaginal dryness, insomnia and mood disturbances [2]. The mean duration is four years but in about 10% of women, they may continue for up till 12 years [3]. Menopausal hormone therapy is recommended as the most effective treatment for vasomotor symptoms [4]. Options are unopposed estrogen, combined therapy (estrogen and progestogen) or tibolone.
Source: Maturitas - Category: Primary Care Authors: Tags: Review article Source Type: research