Wnt / ß-Catenin Signaling Pathway Against Aβ Toxicity in PC12 Cells.

CONCLUSION: These findings are first to demonstrate that Wnt/β-catenin signaling pathway regulates Aβ25-35-induced apoptosis. PMID: 27318974 [PubMed - as supplied by publisher]
Source: Neuro-Signals - Category: Neurology Authors: Tags: Neurosignals Source Type: research

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Publication date: Available online 20 January 2020Source: NeurocomputingAuthor(s): Wei Li, Xuefeng Lin, Xi ChenAbstractApplying machine learning methods to various modality medical images and clinical data for early diagnosis of Alzheimer's disease (AD) and its prodromal stage has got lots of significant results. So far, the image data input to classifier mainly focus on 2D or 3D images. Although some functional imaging technologies, such as functional magnetic resonance imaging (fMRI), generate 4D data which contain both spatial and time-varying information of the brain, for the lack of suitable 4D image processing algori...
Source: Neurocomputing - Category: Neuroscience Source Type: research
Very early research suggests a novel, noninvasive brain stimulation technique guided by ultrasound may improve memory in Alzheimer's disease.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Psychiatry News Source Type: news
The J.P. Morgan Healthcare conference runs every year in San Francisco, a big draw for the biotech industry, and many organizations take the opportunity to host events at the same time. Among these, the SENS Research Foundation has for the past few years hosted a pitch day in which biotech companies in the longevity industry, largely startups, present to that portion of the Bay Area investor community interested in funding the treatment of aging as a medical condition. I was there to present on progress at Repair Biotechnologies, and took some notes on the other companies as they talked about their work. Kimera Labs ...
Source: Fight Aging! - Category: Research Authors: Tags: Investment Source Type: blogs
Publication date: Available online 20 January 2020Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Li Kong, Edgar Dawkins, Frederick Campbell, Edith Winkler, Rico J.E. Derks, Martin Giera, Frits Kamp, Harald Steiner, Alexander KrosAbstractThe biophysical properties and biological functions of membranes are highly dependent on lipid composition. Supplementing cellular membranes with very long chain fatty acids (vlcFAs) is notoriously difficult given the extreme insolubility of vlcFAs in aqueous solution. Herein, we report a solvent-free, photochemical approach to enrich target membranes with vlcFA. To pr...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Our study aimed at the development of a method based on ultra-performance liquid chromatography coupled to mass spectrometry (UPLC-ESI-MS) using selected ion monitoring for the simultaneous quantitation of the alkaloids galantamine, pseudolycorine, sanguinine and narciclasine in Amaryllidaceae species (Hippeastrum elegans, Habranthus cf. irwinianus, Hymenocallis littoralis and Griffinia nocturna). The alkaloids were extracted from dried and ground bulbs (100 mg) using liquid-liquid microextraction followed by solid phase extraction in cation exchange cartridges. The quantification method showed good linearity (correlation ...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
Wearable technology allows an in-depth analysis of gait behaviour in free-living environments. This investigation aimed to use Alzheimer's disease as an example to apply the time series analysis technique of Statistical Parametric Mapping (SPM) to create d...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Myelin is the sheathing of nerves, essential to their function. Excessive loss produces disabling and ultimately fatal conditions such as multiple sclerosis, but we all lose myelin integrity to some degree as a consequence of the damage and dysfunction of degenerative aging. This most likely contributes to cognitive decline and other age-related issues. A number of different approaches have been identified to boost the operation of the normal maintainance processes that remyelinate nerves, such as FGF21 upregulation, or increasing the size of remyelinating cell populations. Here, researchers discover another possible trigg...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
DEMENTIA is a term used to describe conditions affecting the brain, such as Alzheimer ’s disease. Currently there’s no cure, but research has suggested ways it can be prevented. One way to prevent dementia could be to keep reading.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Source: Neuropsychiatric Disease and Treatment - Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
AbstractMurraya koenigii is a medicinal plant that contains several carbazole-type alkaloids as its characteristic constituents. Blood –brain barrier permeable constituents ofM. koenigii accelerated neurite outgrowth in PC-12 cells. Nine compounds were isolated fromM. koenigii and their effects on neurite outgrowth were examined. Murrayamine-E (8) at 10  μM showed significant effect. Focusing on the carbazole skeleton, we synthesized derivatives to attenuate cytotoxicity. 9-Benzyl-9H-carbazol-4-ol (15) exhibited strong neurite outgrowth accelerative effect. In addition, the novel object recognition test and t...
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research
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