Efficacy and tolerability of Z-drug adjunction to antidepressant treatment for major depressive disorder: a systematic review and meta-analysis of randomized controlled trials

In conclusion, Z-drugs + antidepressants improves the treatment efficacy for MDD compared with the placebo + antidepressants/antidepressants alone. However, the therapy requires close monitoring of adverse events, particularly dizziness.

http://link.springer.com/10.1007/s00406-016-0706-5

Source: European Archives of Psychiatry and Clinical Neuroscience - June 17, 2016 Category: Neuroscience Source Type: research