Recent years have witnessed an explosion of knowledge about genetic causes of infantile epileptic encephalopathies. Many of these syndromes were previously considered symptomatic of unknown etiology or, simply, cryptogenic. These discoveries are providing insights into the underlying pathophysiology of these epileptic syndromes as well as novel opportunities for better diagnosis, prognostication, genetic counseling and even precision therapies. With the ever accelerating pace of research and discovery in this field, there is, thus, an increasingly widening gap in the knowledge of clinicians of the full range of recent discoveries, their clinical correlates, when and how to test for the underlying genetic etiologies, how to interpret the results of the genetic testing and how to use these results to prognosticate and to treat.
In the face of COVID-19, neurologists working in stroke, epilepsy, dementia, and other subspecialties are tasked with a quick pivot from in-office patient visits to a new era of online consultations.Medscape Medical News
Publication date: May 2020Source: Epilepsy &Behavior, Volume 106Author(s): Kuo-Liang Chiang, Chin-Yin Huang, Liang-Po Hsieh, Kai-Ping Chang
In conclusion, microelectrode implantation surgeries modified some physiological and pathological behaviours; therefore, it is important to consider this fact when it is working with animal models. PMID: 32211080 [PubMed - in process]
Abstract Preeclampsia is a dangerous hypertensive disorder of pregnancy with known links to negative child health outcomes. Here, we review epidemiological and basic neuroscience work from the past several decades linking prenatal preeclampsia to altered neurodevelopment. This work demonstrates increased rates of neuropsychiatric disorders [e.g., increased autism spectrum disorder, attention deficit hyperactivity disorder (ADHD)] in children of preeclamptic pregnancies, as well as increased rates of cognitive impairments [e.g., decreased intelligence quotient (IQ), academic performance] and neurological disease (e...
ConclusionMost patients with temporal lobe epilepsy and CSF GAD65-Abs develop a chronic disease with progressive cognitive impairment and refractory epilepsy regardless of the presence of additional limbic symptoms at onset.
The review highlights contemporary views on the problem of suicide in patients with epilepsy. The most relevant theories are presented that describe the emergence of suicidal thoughts and the transition to suicidal attempts. Along with a description of ris...
AIM: To study a role of psychopathological and social factors in the development of suicidal behavior in patients with different forms of epilepsy. MATERIAL AND METHODS: One hundred and nineteen patients with epilepsy, 57 men and 62 women, mean age 40.7 ±0...
Publication date: Available online 25 March 2020Source: NeuroImage: ClinicalAuthor(s): Victoria L. Morgan, Catie Chang, Dario J. Englot, Baxter P. Rogers
Findings may have implications for understanding epilepsy, autism spectrum disorders.
Condition: Epilepsy Intractable Interventions: Procedure: Cathodal Transcranial Direct Current Stimulation; Procedure: Sham Transcranial direct current stimulation Sponsor: University of Campinas, Brazil Recruiting