Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection

More than 59,000 new cases of head and neck cancers are estimated for 2015 in the US alone, including 45,000 cases arising in the oral cavity and pharynx and 13,000 in the larynx, resulting each year in approximately 11,000 cancer-associated deaths (http://seer.cancer.gov/). Most head and neck malignancies are squamous cell carcinoma (HNSCC), which remain associated with a poor outcome [1], primarily due to local tumor recurrence and regional lymph node and distant metastasis, despite of considerable advances in multimodality therapy including surgery, radiation therapy and chemotherapy to control local disease [2].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Tags: Review Source Type: research