Prednisone and Deflazacort in Duchenne Muscular Dystrophy: Do They Play a Different Role in Child Behavior and Perceived Quality of Life?

In this study, we only used the syndrome scales of the CBCL. Syndromes are sets of concurrent problems that tend to co-occur together. Syndrome scales include anxious/depressed, withdrawn/depressed, somatic complaints, social problems, thought problems, attention problems, rule-breaking behavior and aggressive behavior. Syndrome scales are categorized into internalizing and externalizing behaviors. Internalizing behaviors are problems that are primarily within the individual and include anxious/depressed, withdrawn/depressed and somatic complaints, while externalizing behaviors are problems that mainly involve conflict with other people and their expectations for the child and include rule-breaking and aggressive behavior subscales.14 Higher scores on the CBCL indicate more problems. In addition to the completion of the CBCL, parents and boys with DMD completed the PedsQL™ 4.0 generic core scale short form (SF-15).15,16,17 For boys between the ages of 5 and 7 and in situations where the child was unable to read or complete the questionnaire independently because of cognitive impairment, the PedsQL™ was interview-administered by one of the researchers. The PedsQL asks “how much of a problem has your child had with…,” with a score of 0=never and a score of 4=almost always. The PedsQL is reversed scored so that a score of 100 means that the parent/child did not report any problems in this area. Statistical Analysis Boys were divided into three groups acc...
Source: PLOS Currents Muscular Dystrophy - Category: Neurology Authors: Source Type: research